ENSMUSG00000029254


Mus musculus
regulationStap1shdomainreceptorproteinkinasecellbindingtyrosinesignalingpathwaymacrophagemicroglialactivitysuperfamilytransmembranecolony-stimulatingfactoradaptorpleckstrinhomologyph-likestapgeneexpressionchemotaxismyeloiddifferentiationphosphorylationb

Features
Gene ID: ENSMUSG00000029254
  
Biological name :Stap1
  
Synonyms : Q9JM90 / Signal-transducing adaptor protein 1 / Stap1
  
Possible biological names infered from orthology : Q9ULZ2 / signal transducing adaptor family member 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 86071746
Gene end: 86106125
  
Corresponding Affymetrix probe sets: 10522788 (MoGene1.0st)   1421098_at (Mouse Genome 430 2.0 Array)   1440284_at (Mouse Genome 430 2.0 Array)   1443927_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031171
Ensembl peptide - ENSMUSP00000143251
NCBI entrez gene - 56792     See in Manteia.
MGI - MGI:1926193
RefSeq - XM_006535160
RefSeq - NM_001310639
RefSeq - NM_019992
RefSeq Peptide - NP_001297568
RefSeq Peptide - NP_064376
swissprot - Q9JM90
swissprot - A0A0H2UKC0
Ensembl - ENSMUSG00000029254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STAP1ENSGALG00000011684Gallus gallus
 STAP1ENSG00000035720Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stap2 / Q8R0L1 / Signal-transducing adaptor protein 2 / Q9UGK3* / signal transducing adaptor family member 2*ENSMUSG0000003878134


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035877  STAP1, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
cell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell communicationcellular response to stimulusorganic substance metabolic processresponse to external stimulusresponse to chemicallocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processcellular metabolic processimmune responsecellular component organizationestablishment of localizationresponse to biotic stimuluscellular component biogenesiscell activationnitrogen compound metabolic processprimary metabolic processregulation of molecular functionleukocyte mediated cytotoxicityactin filament-based processcell ccell communicationcellulcellular response to stimulusorganiorganic substance metabolic processresponresponse to external stimulusresponresponse to chemicallocalilocalization of cellmovememovement of cell or subcellular componentanatomanatomical structure developmentcellulcellular developmental processcellulcellular metabolic processimmuneimmune responsecellulcellular component organizationestablestablishment of localizationresponresponse to biotic stimuluscellulcellular component biogenesiscell acell activationnitrognitrogen compound metabolic processprimarprimary metabolic processregularegulation of molecular functionleukocleukocyte mediated cytotoxicityactin actin filament-based process
protein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingprotein bindingmolecular adaptor activitymolecular adaptor activity
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010760 negative regulation of macrophage chemotaxis IMP
 biological_processGO:0030099 myeloid cell differentiation TAS
 biological_processGO:0042326 negative regulation of phosphorylation IDA
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:1900028 negative regulation of ruffle assembly IMP
 biological_processGO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway IMP
 biological_processGO:1903980 positive regulation of microglial cell activation IMP
 biological_processGO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity IEA
 biological_processGO:1904140 negative regulation of microglial cell migration IMP
 biological_processGO:1904151 positive regulation of microglial cell mediated cytotoxicity IDA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005157 macrophage colony-stimulating factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr