ENSMUSG00000029338


Mus musculus

Features
Gene ID: ENSMUSG00000029338
  
Biological name :Antxr2
  
Synonyms : Anthrax toxin receptor 2 / Antxr2 / Q6DFX2
  
Possible biological names infered from orthology : P58335
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E3
Gene start: 97882783
Gene end: 98031043
  
Corresponding Affymetrix probe sets: 10531560 (MoGene1.0st)   1426708_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142605
Ensembl peptide - ENSMUSP00000031281
NCBI entrez gene - 71914     See in Manteia.
MGI - MGI:1919164
RefSeq - NM_133738
RefSeq Peptide - NP_598499
swissprot - A0A0G2JE26
swissprot - Q3TCL6
swissprot - Q6DFX2
Ensembl - ENSMUSG00000029338
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 antxr2aENSDARG00000104118Danio rerio
 antxr2bENSDARG00000063011Danio rerio
 ANTXR2ENSGALG00000043675Gallus gallus
 ANTXR2ENSG00000163297Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Antxr1 / Q9CZ52 / Anthrax toxin receptor 1 / Q9H6X2*ENSMUSG0000003342053
Antxrl / Q8BVM2 / Anthrax toxin receptor-like / A6NF34*ENSMUSG0000004744134
AC164099.2ENSMUSG0000011572624


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR008399  Anthrax toxin receptor, C-terminal
 IPR008400  Anthrax toxin receptor, extracellular
 IPR013783  Immunoglobulin-like fold
 IPR017360  Anthrax toxin receptor
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0022414 reproductive process IMP
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dock8tm1Ysfk/Dock8tm1Ysfk
Genetic Background: B6.Cg-Dock8tm1Ysfk

 MP:0001135 abnormal cervix morphology "malformation or malfunctioning of the lower opening of the uterus to the vagina" [MGI:tc]
Show

Allelic Composition: Dock8tm1Ysfk/Dock8tm1Ysfk
Genetic Background: B6.Cg-Dock8tm1Ysfk

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm3.1Mlc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0004038 lymphangiectasis "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816]
Show

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm3.1Mlc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Antxr1tm1.2Lepp/Antxr1tm1.2Lepp,Antxr2tm1.2Lepp/Antxr2tm1.2Lepp
Genetic Background: involves: 129 * C57BL/6

 MP:0009209 abnormal internal female genitalia morphology "any structural anomaly of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Antxr1tm1.2Lepp/Antxr1tm1.2Lepp,Antxr2tm1.2Lepp/Antxr2tm1.2Lepp
Genetic Background: involves: 129 * C57BL/6

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm3.1Mlc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0012010 parturition failure "the process of labor and delivery in female animals does not initiate or complete" [MGI:csmith]
Show

Allelic Composition: Antxr2tm1.1Jkit/Antxr2tm1.1Jkit
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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