ENSMUSG00000029669


Mus musculus

Features
Gene ID: ENSMUSG00000029669
  
Biological name :Tspan12
  
Synonyms : Q8BKT6 / Tetraspanin-12 / Tspan12
  
Possible biological names infered from orthology : O95859
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.1
Gene start: 21771395
Gene end: 21852515
  
Corresponding Affymetrix probe sets: 10543306 (MoGene1.0st)   1454604_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113384
Ensembl peptide - ENSMUSP00000144717
Ensembl peptide - ENSMUSP00000144671
Ensembl peptide - ENSMUSP00000123475
Ensembl peptide - ENSMUSP00000117820
Ensembl peptide - ENSMUSP00000031678
NCBI entrez gene - 269831     See in Manteia.
MGI - MGI:1889818
RefSeq - XM_017321602
RefSeq - XM_017321601
RefSeq - XM_006505090
RefSeq - NM_173007
RefSeq - XM_006505091
RefSeq - XM_011241063
RefSeq Peptide - NP_766595
swissprot - Q8BKT6
swissprot - D3YYV7
swissprot - A0A0J9YVI2
swissprot - A0A0N4SUK4
swissprot - D3YW00
Ensembl - ENSMUSG00000029669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tspan12ENSDARG00000032389Danio rerio
 Q5ZIF5ENSGALG00000009029Gallus gallus
 O95859ENSG00000106025Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000301  Tetraspanin
 IPR008952  Tetraspanin, EC2 domain superfamily
 IPR018499  Tetraspanin/Peripherin
 IPR018503  Tetraspanin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0045765 regulation of angiogenesis IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Allelic Composition: Ndptm1Lex/Ndptm1Lex,Tspan12tm1Wye/Tspan12+
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)

Allelic Composition: Ndptm1Lex/Y,Tspan12tm1Wye/Tspan12+
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)

Allelic Composition: Tspan12tm1Wye/Tspan12+
Genetic Background: either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye

Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5+,Tspan12tm1Wye/Tspan12+
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)

 MP:0004368 abnormal stria vascularis vasculature "any structural anomaly of the blood vessels supplying the stria vascularis in the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0006185 retinal hemorrhage "bleeding into the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0009392 retinal gliosis "increased proliferation of neuroglia in a damaged area of the retina that may lead to the formation of scar tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0010452 retina microaneurysm "focal dilation of arteriocapillary junctions in the retina" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Clcn5tm1Tjj/Clcn5+,Clcn7tm3.1Tjj/Clcn7tm3.1Tjj,Tg(APOE-cre)VITew/0
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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