ENSMUSG00000029697


Mus musculus
bindingFezf1regulationdevelopmenttranscriptiondnaneuronolfactoryrnapolymeraseiidna-templatedcellbulbsequence-specificsmallvomeronasalzincfingerchmigrationaxonforebraindifferentiationproximalpromoterregiondentategyruslethality

Features
Gene ID: ENSMUSG00000029697
  
Biological name :Fezf1
  
Synonyms : Fezf1 / Fez family zinc finger protein 1 / Q0VDQ9
  
Possible biological names infered from orthology : A0PJY2 / FEZ family zinc finger 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.1
Gene start: 23245044
Gene end: 23248362
  
Corresponding Affymetrix probe sets: 10543362 (MoGene1.0st)   1429991_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031709
NCBI entrez gene - 73191     See in Manteia.
MGI - MGI:1920441
RefSeq - NM_028462
RefSeq - XM_006505175
RefSeq Peptide - NP_082738
swissprot - Q0VDQ9
Ensembl - ENSMUSG00000029697
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fezf1ENSDARG00000010270Danio rerio
 FEZF1ENSGALG00000008941Gallus gallus
 FEZF1ENSG00000128610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fezf2 / Q9ESP5 / Fez family zinc finger protein 2 / Q8TBJ5* / FEZ family zinc finger 2*ENSMUSG0000002174353
Q8BGV5 / Zfp128 / zinc finger protein 128 / ZNF8* / P17098* / zinc finger protein 8*ENSMUSG0000006039725
Gfi1 / growth factor independent 1 transcriptional repressor / Q99684*ENSMUSG0000002927522
Gfi1b / O70237 / Zinc finger protein Gfi-1b / Q5VTD9* / growth factor independent 1B transcriptional repressor*ENSMUSG0000002681521


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processresponse to external stimuluscellular component organizationresponse to chemicaldedifferentiationnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular mcellular metabolic processprimary meprimary metabolic processorganic suorganic substance metabolic processlocalizatilocalization of cellmovement omovement of cell or subcellular componentanatomicalanatomical structure developmentcellular dcellular developmental processresponse tresponse to external stimuluscellular ccellular component organizationresponse tresponse to chemicaldedifferendedifferentiation
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor acDNA-binding transcription factor activityion bindingion binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0021797 forebrain anterior/posterior pattern specification IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0043697 cell dedifferentiation IGI
 biological_processGO:0045666 positive regulation of neuron differentiation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0050767 regulation of neurogenesis IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
nervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phenotypegrowth/size phenotypebehavior/neurological phenotypecellular phenotypecraniofacial phenotypetaste/olfaction phenotyperespiratory system phenotypemortality/agingnervous system phnervous system phenotypegrowth/size phenogrowth/size phenotypebehavior/neurologbehavior/neurological phenotypecellular phenotypcellular phenotypecraniofacial phencraniofacial phenotypetaste/olfaction ptaste/olfaction phenotyperespiratory systerespiratory system phenotypemortality/agingmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: B6.129S7-Trp63tm2Brd/J

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: B6.129S7-Trp63tm2Brd/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fezf1tm1Taku/Fezf1tm1Taku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Fezf1tm1Taku/Fezf1tm1Taku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Fezf1tm1.1Bche/Fezf1tm1.1Bche
Genetic Background: involves: CD-1

Allelic Composition: Fezf1tm1.1Bche/Fezf1tm1.1Bche,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fezf1tm1Taku/Fezf1tm1Taku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Fezf1tm1Taku/Fezf1tm1Taku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011679 abnormal vomeronasal sensory neuron morphology "any structural anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MGI:csmith]
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Allelic Composition: Fezf1tm1.1Bche/Fezf1tm1.1Bche,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fezf1tm1.1Bche/Fezf1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

 MP:0013595 absent vomeronasal organ "lacking the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [MGI:csmith]
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Allelic Composition: Fezf1tm1.1Bche/Fezf1tm1.1Bche,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fezf1tm1.1Bche/Fezf1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

 MP:0013597 small vomeronasal organ "reduced size of the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/senses/jacobsonorgan.html, http://en.wikipedia.org/wiki/Vomeronasal_organ#Structure, MGI:csmith]
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Allelic Composition: Fezf1tm1.1Bche/Fezf1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
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Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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