ENSMUSG00000029819


Mus musculus

Features
Gene ID: ENSMUSG00000029819
  
Biological name :Npy
  
Synonyms : Npy / P57774 / Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY
  
Possible biological names infered from orthology : neuropeptide Y / P01303
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.3
Gene start: 49822710
Gene end: 49829507
  
Corresponding Affymetrix probe sets: 10538247 (MoGene1.0st)   1419127_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031843
NCBI entrez gene - 109648     See in Manteia.
MGI - MGI:97374
RefSeq - NM_023456
RefSeq Peptide - NP_075945
swissprot - P57774
Ensembl - ENSMUSG00000029819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npyENSDARG00000036222Danio rerio
 NPYENSGALG00000010983Gallus gallus
 NPYENSG00000122585Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pyy / Q9EPS2 / peptide YY / P10082*ENSMUSG0000001731146


Protein motifs (from Interpro)
Interpro ID Name
 IPR001955  Pancreatic hormone-like
 IPR020392  Pancreatic hormone-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0008217 regulation of blood pressure IDA
 biological_processGO:0008343 adult feeding behavior ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021954 central nervous system neuron development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032098 regulation of appetite IBA
 biological_processGO:0032100 positive regulation of appetite ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IGI
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Asphtm1Egk/Asphtm1Egk
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Asphtm1Egk/Asphtm1Egk
Genetic Background: Not Specified

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Asphtm1Egk/Asphtm1Egk
Genetic Background: Not Specified

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Asphtm1Egk/Asphtm1Egk
Genetic Background: Not Specified

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Asphtm1Egk/Asphtm1Egk
Genetic Background: Not Specified

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0014145 increased white adipose tissue mass "increased physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028004 Npy2r / P97295 / Neuropeptide Y receptor type 2 / P49146* / neuropeptide Y receptor Y2*  / complex / reaction
 ENSMUSG00000036437 Npy1r / Q04573 / Mus musculus neuropeptide Y receptor Y1 (Npy1r), transcript variant 2, mRNA. / P25929* / neuropeptide Y receptor Y1*  / complex / reaction
 ENSMUSG00000044014 Npy5r / O70342 / Mus musculus neuropeptide Y receptor Y5 (Npy5r), transcript variant 2, mRNA. / Q15761* / neuropeptide Y receptor Y5*  / complex / reaction
 ENSMUSG00000048337 Npy4r / Q61041 / Neuropeptide Y receptor type 4 / NPY4R2* / P50391* / neuropeptide Y receptor Y4* / neuropeptide Y receptor Y4-2*  / complex / reaction






 

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