ENSMUSG00000030157


Mus musculus

Features
Gene ID: ENSMUSG00000030157
  
Biological name :Clec2d
  
Synonyms : Clec2d / C-type lectin domain family 2 member D / Q91V08
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F3
Gene start: 129180615
Gene end: 129186534
  
Corresponding Affymetrix probe sets: 10542156 (MoGene1.0st)   1419477_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032260
NCBI entrez gene - 93694     See in Manteia.
MGI - MGI:2135589
RefSeq - XM_006506805
RefSeq - NM_053109
RefSeq Peptide - NP_444339
swissprot - Q91V08
swissprot - F5BFH0
Ensembl - ENSMUSG00000030157
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045134Gallus gallus
 ENSGALG00000044598Gallus gallus
 ENSGALG00000046229Gallus gallus
 ENSGALG00000039340Gallus gallus
 ENSGALG00000045081Gallus gallus
 ENSGALG00000044569Gallus gallus
 ENSGALG00000045290Gallus gallus
 ENSGALG00000045880Gallus gallus
 ENSGALG00000044633Gallus gallus
 ENSGALG00000045540Gallus gallus
 ENSGALG00000045053Gallus gallus
 BLEC1ENSGALG00000028659Gallus gallus
 BLEC3ENSGALG00000031092Gallus gallus
 Y-LEC1ENSGALG00000042684Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec2g / Q9D676 / C-type lectin domain family 2 member G ENSMUSG0000000024878
Clec2i / Q9WVF9 / C-type lectin domain family 2 member I ENSMUSG0000003036566
Clec2eENSMUSG0000003015555
Clec2h / Q8C1T8 / C-type lectin domain family 2 member H ENSMUSG0000003036452
Clec2l / P0C7M9 / C-type lectin domain family 2 member L / P0C7M8*ENSMUSG0000007959823
Cd69 / P37217 / Early activation antigen CD69 / Q07108* / CD69 molecule*ENSMUSG0000003015622
Klrg2 / killer cell lectin like receptor G2 / A4D1S0*ENSMUSG0000007153722
4922502D21Rik / RIKEN cDNA 4922502D21 geneENSMUSG0000004772020
Klrg1 / O88713 / Killer cell lectin-like receptor subfamily G member 1 / Q96E93* / killer cell lectin like receptor G1*ENSMUSG0000003011417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042270 protection from natural killer cell mediated cytotoxicity IGI
 biological_processGO:0045671 negative regulation of osteoclast differentiation IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding ISS
 molecular_functionGO:0046703 natural killer cell lectin-like receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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