ENSMUSG00000030255


Mus musculus

Features
Gene ID: ENSMUSG00000030255
  
Biological name :Sspn
  
Synonyms : sarcospan / Sspn
  
Possible biological names infered from orthology : Q14714
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G3
Gene start: 145931641
Gene end: 145965223
  
Corresponding Affymetrix probe sets: 10542740 (MoGene1.0st)   1417644_at (Mouse Genome 430 2.0 Array)   1417645_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032383
Ensembl peptide - ENSMUSP00000107330
Ensembl peptide - ENSMUSP00000107331
NCBI entrez gene - 16651     See in Manteia.
MGI - MGI:1353511
RefSeq - XM_006506916
RefSeq - NM_001310837
RefSeq - NM_010656
RefSeq Peptide - NP_001297766
RefSeq Peptide - NP_034786
swissprot - Q3TRE0
swissprot - E9Q8Y7
Ensembl - ENSMUSG00000030255
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sspnENSDARG00000041747Danio rerio
 SSPNENSGALG00000014042Gallus gallus
 SSPNENSG00000123096Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007237  CD20-like family
 IPR030429  Sarcospan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b
Genetic Background: Not Specified

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpcn1Gt(OST359423)Lex/Tpcn1Gt(OST359423)Lex
Genetic Background: B6;129S5-Tpcn1Gt(OST359423)Lex/Orl

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tpcn1Gt(OST359423)Lex/Tpcn1Gt(OST359423)Lex
Genetic Background: B6;129S5-Tpcn1Gt(OST359423)Lex/Orl

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpcn1Gt(OST359423)Lex/Tpcn1Gt(OST359423)Lex
Genetic Background: B6;129S5-Tpcn1Gt(OST359423)Lex/Orl

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010225 abnormal quadriceps morphology "any structural anomaly of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010226 increased quadriceps weight "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpcn1Gt(OST359423)Lex/Tpcn1Gt(OST359423)Lex
Genetic Background: B6;129S5-Tpcn1Gt(OST359423)Lex/Orl

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga7tm1Burk/Itga7tm1Burk,Sspntm1Kcam/Sspntm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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