ENSMUSG00000030336


Mus musculus

Features
Gene ID: ENSMUSG00000030336
  
Biological name :Cd27
  
Synonyms : Cd27 / CD27 antigen / P41272
  
Possible biological names infered from orthology : CD27 molecule / P26842
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 125232622
Gene end: 125237010
  
Corresponding Affymetrix probe sets: 10547985 (MoGene1.0st)   1452389_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107901
Ensembl peptide - ENSMUSP00000032486
Ensembl peptide - ENSMUSP00000107900
NCBI entrez gene - 21940     See in Manteia.
MGI - MGI:88326
RefSeq - XM_011241288
RefSeq - NM_001033126
RefSeq - NM_001042564
RefSeq - NM_001286753
RefSeq - XM_006505898
RefSeq - XM_006505900
RefSeq - XM_006505901
RefSeq Peptide - NP_001273682
RefSeq Peptide - NP_001028298
RefSeq Peptide - NP_001036029
swissprot - B7ZW87
swissprot - Q3U4X0
swissprot - D3Z7W5
swissprot - P41272
Ensembl - ENSMUSG00000030336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD27ENSG00000139193Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR022328  Tumour necrosis factor receptor 7
 IPR034000  Tumour necrosis factor receptor 7, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042100 B cell proliferation NAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process NAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0048305 immunoglobulin secretion NAS
 biological_processGO:0070233 negative regulation of T cell apoptotic process IPI
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019489 Cd70 / O55237 / CD70 antigen / P32970* / CD70 molecule*  / complex / reaction






 

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