ENSMUSG00000030376


Mus musculus

Features
Gene ID: ENSMUSG00000030376
  
Biological name :Slc8a2
  
Synonyms : Q8K596 / Slc8a2 / solute carrier family 8 (sodium/calcium exchanger), member 2
  
Possible biological names infered from orthology : Q9UPR5 / solute carrier family 8 member A2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16129826
Gene end: 16161063
  
Corresponding Affymetrix probe sets: 10550263 (MoGene1.0st)   1428054_at (Mouse Genome 430 2.0 Array)   1438262_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128926
Ensembl peptide - ENSMUSP00000147497
NCBI entrez gene - 110891     See in Manteia.
MGI - MGI:107996
RefSeq - XM_006539472
RefSeq - NM_148946
RefSeq - XM_006539470
RefSeq - XM_006539471
RefSeq Peptide - NP_001334490
RefSeq Peptide - NP_683748
swissprot - Q8K596
Ensembl - ENSMUSG00000030376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc8a2aENSDARG00000008912Danio rerio
 slc8a2bENSDARG00000100592Danio rerio
 Q9UPR5ENSG00000118160Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S4R2P9 / Slc8a3 / solute carrier family 8 (sodium/calcium exchanger), member 3 / P57103* / solute carrier family 8 member A3*ENSMUSG0000007905568
Slc8a1 / solute carrier family 8 (sodium/calcium exchanger), member 1 / P32418* / solute carrier family 8 member A1*ENSMUSG0000005464066
Adgrv1 / Q8VHN7 / adhesion G protein-coupled receptor V1 / Q8WXG9*ENSMUSG0000006917027


Protein motifs (from Interpro)
Interpro ID Name
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR004836  Sodium/calcium exchanger protein
 IPR004837  Sodium/calcium exchanger membrane region
 IPR032452  Sodium/calcium exchanger domain, C-terminal extension


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0035725 sodium ion transmembrane transport IMP
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0070588 calcium ion transmembrane transport IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005432 calcium:sodium antiporter activity IMP
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0002921 abnormal post-tetanic potential "defects in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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