ENSMUSG00000030538


Mus musculus

Features
Gene ID: ENSMUSG00000030538
  
Biological name :Cib1
  
Synonyms : Calcium and integrin-binding protein 1 / Cib1 / Q9Z0F4
  
Possible biological names infered from orthology : calcium and integrin binding 1 / Q99828
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 80227147
Gene end: 80232813
  
Corresponding Affymetrix probe sets: 10564869 (MoGene1.0st)   1425856_at (Mouse Genome 430 2.0 Array)   1448564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071401
Ensembl peptide - ENSMUSP00000146153
Ensembl peptide - ENSMUSP00000145961
Ensembl peptide - ENSMUSP00000145564
Ensembl peptide - ENSMUSP00000118926
Ensembl peptide - ENSMUSP00000070901
NCBI entrez gene - 23991     See in Manteia.
MGI - MGI:1344418
RefSeq - XM_011250861
RefSeq - NM_001291275
RefSeq - NM_001291276
RefSeq - NM_011870
RefSeq Peptide - NP_001278204
RefSeq Peptide - NP_001278205
RefSeq Peptide - NP_036000
swissprot - A0A0U1RPF3
swissprot - A0A0U1RNH3
swissprot - Q8C2K4
swissprot - A0A0U1RPW6
swissprot - Q9Z0F4
swissprot - D3YY46
Ensembl - ENSMUSG00000030538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cib1ENSDARG00000103118Danio rerio
 CIB1ENSGALG00000008302Gallus gallus
 CIB1ENSG00000185043Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cib4 / Q9D9N5 / Calcium and integrin-binding family member 4 / A0PJX0*ENSMUSG0000005319440
Cib2 / Q9Z309 / Calcium and integrin-binding family member 2 / O75838*ENSMUSG0000003749335
Cib3 / Q0P523 / Calcium and integrin-binding family member 3 / Q96Q77*ENSMUSG0000007424032


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IMP
 biological_processGO:0002931 response to ischemia IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006915 apoptotic process ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007026 negative regulation of microtubule depolymerization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007113 endomitotic cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031122 cytoplasmic microtubule organization IEA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0038163 thrombopoietin-mediated signaling pathway IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051302 regulation of cell division IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000256 positive regulation of male germ cell proliferation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0032433 filopodium tip ISO
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008427 calcium-dependent protein kinase inhibitor activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0043495 protein membrane anchor IMP
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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