MP:0000336 | decreased mast cell number | "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0005027 | increased susceptibility to parasitic infection | "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0005466 | abnormal T helper 2 physiology | "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions
" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008091 | decreased T-helper 2 cell number | "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008246 | abnormal leukocyte morphology | "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008567 | decreased interferon-gamma secretion | "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008568 | abnormal interleukin secretion | "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008603 | decreased circulating interleukin-4 level | "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008673 | decreased interleukin-13 secretion | "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008697 | decreased interleukin-3 secretion | "reduction in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008700 | decreased interleukin-4 secretion | "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
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MP:0008703 | decreased interleukin-5 secretion | "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki Genetic Background: involves: 129/Sv * C57BL/6
|