ENSMUSG00000030722


Mus musculus

Features
Gene ID: ENSMUSG00000030722
  
Biological name :Nfatc2ip
  
Synonyms : NFATC2-interacting protein / Nfatc2ip / O09130
  
Possible biological names infered from orthology : nuclear factor of activated T cells 2 interacting protein / Q8NCF5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126382854
Gene end: 126396737
  
Corresponding Affymetrix probe sets: 10567851 (MoGene1.0st)   1434836_at (Mouse Genome 430 2.0 Array)   1451781_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145755
Ensembl peptide - ENSMUSP00000075094
NCBI entrez gene - 18020     See in Manteia.
MGI - MGI:1329015
RefSeq - NM_010900
RefSeq - XM_006507430
RefSeq Peptide - NP_035030
swissprot - A0A0U1RNY9
swissprot - O09130
Ensembl - ENSMUSG00000030722
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc2ipENSDARG00000011360Danio rerio
 Q8NCF5ENSG00000176953Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR022617  Rad60/SUMO-like domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0016925 protein sumoylation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031386 protein tag IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008091 decreased T-helper 2 cell number "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008697 decreased interleukin-3 secretion "reduction in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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