ENSMUSG00000030981


Mus musculus

Features
Gene ID: ENSMUSG00000030981
  
Biological name :Mmp21
  
Synonyms : matrix metallopeptidase 21 / Mmp21 / Q8K3F2
  
Possible biological names infered from orthology : Q8N119
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 133674270
Gene end: 133680061
  
Corresponding Affymetrix probe sets: 10568629 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000033278
Ensembl peptide - ENSMUSP00000113853
NCBI entrez gene - 214766     See in Manteia.
MGI - MGI:2664387
RefSeq - NM_152944
RefSeq - NM_001320216
RefSeq Peptide - NP_001307145
RefSeq Peptide - NP_694423
swissprot - Q3KP73
swissprot - Q3KP74
swissprot - Q8K3F2
Ensembl - ENSMUSG00000030981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp21ENSDARG00000112495Danio rerio
 MMP21ENSG00000154485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp28 / matrix metallopeptidase 28 (epilysin) / Q9H239* / matrix metallopeptidase 28*ENSMUSG0000002068226
Mmp19 / Q9JHI0 / Matrix metalloproteinase-19 / Q99542* / matrix metallopeptidase 19*ENSMUSG0000002535525
Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*ENSMUSG0000003174024
Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*ENSMUSG0000001773723
Mmp23 / O88676 / Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form / MMP23B* / O75900* / matrix metallopeptidase 23B*ENSMUSG0000002906115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0061371 determination of heart left/right asymmetry ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cc2d2ab2b1035Clo/Cc2d2ab2b1035Clo
Genetic Background: C57BL/6J-Cc2d2ab2b1035Clo

Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

 MP:0006123 tricuspid valve atresia "congenital closure of the tricuspid valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cc2d2ab2b1035Clo/Cc2d2ab2b1035Clo
Genetic Background: C57BL/6J-Cc2d2ab2b1035Clo

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Cc2d2ab2b1035Clo/Cc2d2ab2b1035Clo
Genetic Background: C57BL/6J-Cc2d2ab2b1035Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

 MP:0010422 heart right ventricle hypoplasia "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

 MP:0011665 d-loop transposition of the great arteries "complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing" [PMID:17159076]
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Allelic Composition: Cc2d2ab2b1035Clo/Cc2d2ab2b1035Clo
Genetic Background: C57BL/6J-Cc2d2ab2b1035Clo

Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

 MP:0011668 double outlet right ventricle, Taussig bing type "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]
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Allelic Composition: Mmp21b2b2458Clo/Mmp21b2b2458Clo
Genetic Background: C57BL/6J-Mmp21b2b2458Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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