ENSMUSG00000031155


Mus musculus

Features
Gene ID: ENSMUSG00000031155
  
Biological name :Pim2
  
Synonyms : Pim2 / Q62070 / Serine/threonine-protein kinase pim-2
  
Possible biological names infered from orthology : Pim-2 proto-oncogene, serine/threonine kinase / Q9P1W9
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 7878262
Gene end: 7883432
  
Corresponding Affymetrix probe sets: 10598467 (MoGene1.0st)   1417216_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033495
Ensembl peptide - ENSMUSP00000152537
NCBI entrez gene - 18715     See in Manteia.
MGI - MGI:97587
RefSeq - NM_138606
RefSeq Peptide - NP_613072
swissprot - F6WGR1
swissprot - Q62070
Ensembl - ENSMUSG00000031155
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIM2ENSG00000102096Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pim3 / P58750 / proviral integration site 3 / Q86V86* / Pim-3 proto-oncogene, serine/threonine kinase*ENSMUSG0000003582847
Pim1 / Pim-1 proto-oncogene, serine/threonine kinase / P11309*ENSMUSG0000002401445
Pask / Q8CEE6 / PAS domain-containing serine/threonine-protein kinase / Q96RG2* / PAS domain containing serine/threonine kinase*ENSMUSG0000002627431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017348  Serine/threonine-protein kinase pim-1/2/3
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0050821 protein stabilization IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0003133 increased number of early pro-B cells "greater number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [J:91592, smb:Susan M. Bello, Mouse Genome Informatics Curator, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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