ENSMUSG00000031165


Mus musculus

Features
Gene ID: ENSMUSG00000031165
  
Biological name :Was
  
Synonyms : P70315 / Was / Wiskott-Aldrich syndrome
  
Possible biological names infered from orthology : P42768
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 8081453
Gene end: 8090498
  
Corresponding Affymetrix probe sets: 10603440 (MoGene1.0st)   1419631_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033505
NCBI entrez gene - 22376     See in Manteia.
MGI - MGI:105059
RefSeq - NM_009515
RefSeq Peptide - NP_033541
swissprot - P70315
swissprot - Q53WY0
Ensembl - ENSMUSG00000031165
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wasaENSDARG00000015149Danio rerio
 wasbENSDARG00000026350Danio rerio
 WASENSG00000015285Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*ENSMUSG0000002968445


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000697  WH1/EVH1 domain
 IPR003124  WH2 domain
 IPR011026  Wiscott-Aldrich syndrome protein, C-terminal
 IPR011993  PH-like domain superfamily
 IPR027641  Wiskott-Aldrich syndrome protein
 IPR033927  WASP family, EVH1 domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002625 regulation of T cell antigen processing and presentation IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0008064 regulation of actin polymerization or depolymerization IEA
 biological_processGO:0008154 actin polymerization or depolymerization IDA
 biological_processGO:0010591 regulation of lamellipodium assembly IEA
 biological_processGO:0016197 endosomal transport IDA
 biological_processGO:0030041 actin filament polymerization IDA
 biological_processGO:0030048 actin filament-based movement IDA
 biological_processGO:0032488 Cdc42 protein signal transduction IEA
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:2000146 negative regulation of cell motility IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031267 small GTPase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ay/a
Genetic Background: involves: KK

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: B6.129P2-Hhextm1Rbe

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ay/a
Genetic Background: involves: KK

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: B6.129P2-Hhextm1Rbe

Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: B6.129P2-Hhextm1Rbe

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ay/a
Genetic Background: involves: KK

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ay/a
Genetic Background: involves: KK

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ay/a
Genetic Background: involves: KK

Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ay/a
Genetic Background: involves: KK

Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: BALB/c

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxm1tm1Cle/Foxm1tm1Cle
Genetic Background: Not Specified

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ay/a
Genetic Background: involves: KK

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002827 abnormal renal corpuscle "anomalous structure or development of either Bowman s capsules and/or the glomeruli contained therein" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: BALB/c

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Was+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs,Wasltm2Sbs/Wasltm2Sbs,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Wastm1.1Ldn
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Wastm1.1Ldn/Y
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rassf1tm1Gpp/Rassf1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Wastm1Itl/Wastm1Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Y
Genetic Background: Not Specified

Allelic Composition: Wastm2Itl/Wastm2Itl
Genetic Background: Not Specified

Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006699 Cdc42 / P60766 / Cell division control   / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction






 

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