ENSMUSG00000031245


Mus musculus

Features
Gene ID: ENSMUSG00000031245
  
Biological name :Hmgn5
  
Synonyms : High mobility group nucleosome-binding domain-containing protein 5 / Hmgn5 / Q9JL35
  
Possible biological names infered from orthology : high mobility group nucleosome binding domain 5 / P82970
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 109004534
Gene end: 109013404
  
Corresponding Affymetrix probe sets: 10606436 (MoGene1.0st)   1418152_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033597
NCBI entrez gene - 50887     See in Manteia.
MGI - MGI:1355295
RefSeq - NM_016710
RefSeq Peptide - NP_057919
swissprot - Q9JL35
Ensembl - ENSMUSG00000031245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HMGN5ENSG00000198157Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000079  High mobility group protein HMGN


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006749 glutathione metabolic process IMP
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0031492 nucleosomal DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

Allelic Composition: Hmgn5tm1.1Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002297 abnormal forced expiratory flow rates "anomaly in the rates of airflow during forced vital capacity determination" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002304 abnormal total lung capacity "anomaly in the volume of air contained in the lungs at the end of maximal inspiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002311 abnormal inspiratory capacity "anomaly in the maximal volume of air that can be inspired after the end of a normal expiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

Allelic Composition: Hmgn5tm1.2Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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