ENSMUSG00000031303


Mus musculus

Features
Gene ID: ENSMUSG00000031303
  
Biological name :Map3k15
  
Synonyms : A2AQW0 / Map3k15 / Mitogen-activated protein kinase kinase kinase 15
  
Possible biological names infered from orthology : Q6ZN16
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F4
Gene start: 159988433
Gene end: 160123351
  
Corresponding Affymetrix probe sets: 10602865 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000033665
NCBI entrez gene - 270672     See in Manteia.
MGI - MGI:2448588
RefSeq - NM_001163085
RefSeq Peptide - NP_001156557
swissprot - A2AQW0
Ensembl - ENSMUSG00000031303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k15ENSDARG00000013310Danio rerio
 MAP3K15ENSGALG00000016426Gallus gallus
 Q6ZN16ENSG00000180815Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k5 / O35099 / Mitogen-activated protein kinase kinase kinase 5 / Q99683*ENSMUSG0000007136956
Map3k6 / mitogen-activated protein kinase kinase kinase 6 / O95382*ENSMUSG0000002886242


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025136  Domain of unknown function DUF4071


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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