ENSMUSG00000031372


Mus musculus

Features
Gene ID: ENSMUSG00000031372
  
Biological name :Trex2
  
Synonyms : Q9R1A9 / three prime repair exonuclease 2 / Trex2
  
Possible biological names infered from orthology : Q9BQ50
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 73433705
Gene end: 73435344
  
Corresponding Affymetrix probe sets: 10605051 (MoGene1.0st)   1449367_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033738
NCBI entrez gene - 24102     See in Manteia.
MGI - MGI:1346343
RefSeq - NM_011907
RefSeq Peptide - NP_036037
swissprot - Q3SXB3
swissprot - Q9R1A9
Ensembl - ENSMUSG00000031372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TREX2ENSG00000183479Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trex1 / Q91XB0 / Three-prime repair exonuclease 1 / Q9NSU2*ENSMUSG0000004973445
Gm42641 / TREX1* / Q9NSU2* / three prime repair exonuclease 1*ENSMUSG0000010538329


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR034926  Three prime repair exonuclease 2
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008296 3"-5"-exodeoxyribonuclease activity ISO
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0008853 exodeoxyribonuclease III activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
Show

Allelic Composition: Rev1tm1.1Jow/Rev1tm1.1Jow
Genetic Background: involves: C57BL/6

Allelic Composition: Trex2tm1.2Coso/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rev1tm1.1Jow/Rev1tm1.1Jow
Genetic Background: involves: C57BL/6

Allelic Composition: Trex2tm1.2Coso/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rev1tm1.1Jow/Rev1tm1.1Jow
Genetic Background: involves: C57BL/6

Allelic Composition: Trex2tm1.2Coso/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0009581 decreased keratinocyte apoptosis "reduction in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rev1tm1.1Jow/Rev1tm1.1Jow
Genetic Background: involves: C57BL/6

Allelic Composition: Trex2tm1.2Coso/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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