ENSMUSG00000031385


Mus musculus

Features
Gene ID: ENSMUSG00000031385
  
Biological name :Plxnb3
  
Synonyms : Plexin-B3 / Plxnb3 / Q9QY40
  
Possible biological names infered from orthology : Q9ULL4
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 73757090
Gene end: 73772514
  
Corresponding Affymetrix probe sets: 10600249 (MoGene1.0st)   1418750_at (Mouse Genome 430 2.0 Array)   1440813_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002079
NCBI entrez gene - 140571     See in Manteia.
MGI - MGI:2154240
RefSeq - XM_006527787
RefSeq - NM_019587
RefSeq - XM_006527784
RefSeq - XM_006527786
RefSeq - XM_006527779
RefSeq - XM_006527780
RefSeq - XM_006527781
RefSeq - XM_006527782
RefSeq - XM_006527783
RefSeq Peptide - NP_062533
swissprot - Q9QY40
Ensembl - ENSMUSG00000031385
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnb3ENSDARG00000032990Danio rerio
 PLXNB3ENSG00000198753Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plxnb1 / Q8CJH3 / plexin B1 / O43157*ENSMUSG0000005364651
B2RXS4 / Plxnb2 / plexin B2 / O15031*ENSMUSG0000003660639
P70207 / Plxna2 / Plexin-A2 / O75051*ENSMUSG0000002664033
Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*ENSMUSG0000002976533
P70206 / Plxna1 / Plexin-A1 / Q9UIW2*ENSMUSG0000003008433
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012333
P70208 / Plxna3 / plexin A3 / P51805*ENSMUSG0000003139832
Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*ENSMUSG0000007478522


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0010593 negative regulation of lamellipodium assembly IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0048675 axon extension IBA
 biological_processGO:0050772 positive regulation of axonogenesis IBA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity ISO
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0051022 Rho GDP-dissociation inhibitor binding IPI
 molecular_functionGO:0098632 cell-cell adhesion mediator activity IEA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022231 Sema5a / sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A / Q13591* / semaphorin 5A*  / complex / reaction






 

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