| MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000539 | distended urinary bladder | "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000540 | abnormal urinary bladder epithelium morphology | "malformation of the epithelial layer of the urinary bladder" [MGI:tc] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000822 | abnormal brain ventricle morphology | "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001511 | disheveled coat | "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001524 | impaired limb coordination | "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001655 | multifocal hepatic necrosis | "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kittm1Ber/Kit+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0003624 | anuria | "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0004195 | abnormal calyx morphology | "any structural anomaly of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0004970 | kidney atrophy | "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0005058 | abnormal lysosome morphology | "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0005302 | neurogenic bladder | "defective functioning of the bladder due to impaired innervation, either within the CNS or the PNS" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0008540 | abnormal cerebrum morphology | "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287] |
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Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0009643 | abnormal urine homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0011346 | renal tubule atrophy | "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0011413 | colorless urine | "absence of the usual straw-coloration of the urine" [MGI:anna] |
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0011516 | aspartylglucosaminuria | "high urinary levels of aspartylglucosamine, a derivative of aspartic acid; caused by deficient activity of the enzyme N-aspartyl-beta-glucosaminidase (aspartylglucosaminidase) which normally cleaves long sugar chains known as oligosaccharides in the lysosome" [MGI:anna] |
Show
Allelic Composition: Htr1atm1Tct/Htr1a+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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