ENSMUSG00000031549


Mus musculus

Features
Gene ID: ENSMUSG00000031549
  
Biological name :Ido2
  
Synonyms : Ido2 / Indoleamine 2,3-dioxygenase 2 / Q8R0V5
  
Possible biological names infered from orthology : Q6ZQW0
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 24531892
Gene end: 24576333
  
Corresponding Affymetrix probe sets: 10577645 (MoGene1.0st)   1425778_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113979
NCBI entrez gene - 209176     See in Manteia.
MGI - MGI:2142489
RefSeq - XM_011242131
RefSeq - NM_145949
RefSeq - XM_006509047
RefSeq - XM_006509048
RefSeq - XM_006509046
RefSeq Peptide - NP_666061
swissprot - Q8R0V5
Ensembl - ENSMUSG00000031549
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ido1ENSDARG00000033594Danio rerio
 ENSGALG00000024085Gallus gallus
 IDO2ENSG00000188676Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ido1 / P28776 / Indoleamine 2,3-dioxygenase 1 / P14902*ENSMUSG0000003155143


Protein motifs (from Interpro)
Interpro ID Name
 IPR000898  Indoleamine 2,3-dioxygenase
 IPR037217  Tryptophan/Indoleamine 2,3-dioxygenase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006569 tryptophan catabolic process IEA
 biological_processGO:0019441 tryptophan catabolic process to kynurenine ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004833 tryptophan 2,3-dioxygenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0033754 indoleamine 2,3-dioxygenase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Tryptophan catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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