ENSMUSG00000031772


Mus musculus

Features
Gene ID: ENSMUSG00000031772
  
Biological name :Cntnap4
  
Synonyms : Cntnap4 / Contactin-associated protein-like 4 / Q99P47
  
Possible biological names infered from orthology : Q9C0A0
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 112570043
Gene end: 112882717
  
Corresponding Affymetrix probe sets: 10575630 (MoGene1.0st)   1419044_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112511
Ensembl peptide - ENSMUSP00000034225
NCBI entrez gene - 170571     See in Manteia.
MGI - MGI:2183572
RefSeq - NM_130457
RefSeq - XM_006530729
RefSeq Peptide - NP_569724
swissprot - D3YWB9
swissprot - Q99P47
Ensembl - ENSMUSG00000031772
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000023179Gallus gallus
 Q9C0A0ENSG00000152910Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cntnap3 / contactin associated protein-like 3 / Q96NU0* / Q9BZ76* / CNTNAP3B* / BX088645.1* / contactin associated protein like 3B*ENSMUSG0000003306362
Q0V8T9 / Cntnap5a / Contactin-associated protein like 5-1 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000007069554
Q0V8T7 / Cntnap5c / Contactin-associated protein like 5-3 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000003804853
Q0V8T8 / Cntnap5b / Contactin-associated protein like 5-2 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000006702852
Q9CPW0 / Cntnap2 / Contactin-associated protein-like 2 / Q9UHC6*ENSMUSG0000003941948
O54991 / Cntnap1 / Contactin-associated protein 1 / P78357*ENSMUSG0000001716737
Nrxn2 / neurexin II / P58401* / Q9P2S2* / neurexin 2*ENSMUSG0000003376824
Nrxn1 / P0DI97 / Q9CS84 / Neurexin-1 / P58400* / Q9ULB1*ENSMUSG0000002410923
Nrxn3 / Q6P9K9 / Q8C985 / Neurexin-3 / Q9Y4C0* / Q9HDB5*ENSMUSG0000006639223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR028875  Contactin-associated protein-like 4
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0032225 regulation of synaptic transmission, dopaminergic IMP
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IMP
 biological_processGO:2000821 regulation of grooming behavior IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mad2l2repro22/Mad2l2repro22
Genetic Background: C3.B6(Cg)-Mad2l2repro22

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mad2l2repro22/Mad2l2repro22
Genetic Background: C3.B6(Cg)-Mad2l2repro22

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mad2l2repro22/Mad2l2repro22
Genetic Background: C3.B6(Cg)-Mad2l2repro22

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mad2l2repro22/Mad2l2repro22
Genetic Background: C3.B6(Cg)-Mad2l2repro22

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
Show

Allelic Composition: Mad2l2repro22/Mad2l2repro22
Genetic Background: C3.B6(Cg)-Mad2l2repro22

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Mad2l2repro22/Mad2l2repro22
Genetic Background: C3.B6(Cg)-Mad2l2repro22

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
Show

Allelic Composition: Mad2l2repro22/Mad2l2repro22
Genetic Background: C3.B6(Cg)-Mad2l2repro22

Allelic Composition: Cntnap4tm1Pele/Cntnap4tm1Pele
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr