ENSMUSG00000031831


Mus musculus

Features
Gene ID: ENSMUSG00000031831
  
Biological name :Dnaaf1
  
Synonyms : Dnaaf1 / Dynein assembly factor 1, axonemal / Q9D2H9
  
Possible biological names infered from orthology : dynein axonemal assembly factor 1 / Q8NEP3
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 119575235
Gene end: 119598454
  
Corresponding Affymetrix probe sets: 10575894 (MoGene1.0st)   1421974_at (Mouse Genome 430 2.0 Array)   1450441_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090790
NCBI entrez gene - 68270     See in Manteia.
MGI - MGI:1915520
RefSeq - NM_026648
RefSeq Peptide - NP_080924
swissprot - Q9D2H9
Ensembl - ENSMUSG00000031831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnaaf1ENSDARG00000012030Danio rerio
 DNAAF1ENSGALG00000003258Gallus gallus
 DNAAF1ENSG00000154099Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc9 / Q8CDN9 / Leucine-rich repeat-containing protein 9 / Q6ZRR7* / leucine rich repeat containing 9*ENSMUSG0000002109017
Lrguk / Q9D5S7 / Leucine-rich repeat and guanylate kinase domain-containing protein / Q96M69* / leucine rich repeats and guanylate kinase domain containing*ENSMUSG0000005621517
Drc3 / Q9D5E4 / Dynein regulatory complex subunit 3 / Q9H069*ENSMUSG0000005659814
Lrrc49 / leucine rich repeat containing 49 / Q8IUZ0*ENSMUSG0000004776611
Ppp1r7 / Q3UM45 / Protein phosphatase 1 regulatory subunit 7 / Q15435*ENSMUSG000000262759
Lrrc23 / O35125 / Leucine-rich repeat-containing protein 23 / Q53EV4* / leucine rich repeat containing 23*ENSMUSG000000301257


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR027734  Dynein assembly factor 1, axonemal
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0003341 cilium movement IEA
 biological_processGO:0003356 regulation of cilium beat frequency IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IEA
 biological_processGO:0036158 outer dynein arm assembly IEA
 biological_processGO:0036159 inner dynein arm assembly IEA
 biological_processGO:0044458 motile cilium assembly ISO
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0060972 left/right pattern formation IEA
 biological_processGO:0070286 axonemal dynein complex assembly IEA
 biological_processGO:0071907 determination of digestive tract left/right asymmetry IEA
 biological_processGO:0071910 determination of liver left/right asymmetry IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dnaaf1m4Bei/Dnaaf1m4Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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