ENSMUSG00000031951


Mus musculus
developmentTmem231membraneproteinembryoniccellvasculatureprojectionciliumciliarytransmembraneuterosmoothenedsignalingpathwayorganizationregulationlocalizationdigitmorphogenesiscamera-typeeyeassemblyneuroepithelialdifferentiationplasmaintegralcomponenttransitionzonemks

Features
Gene ID: ENSMUSG00000031951
  
Biological name :Tmem231
  
Synonyms : Mus musculus transmembrane protein 231 (Tmem231), transcript variant 2, mRNA. / Q3U284 / Tmem231
  
Possible biological names infered from orthology : AC009163.2 / Q9H6L2 / transmembrane protein 231
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 111912011
Gene end: 111933881
  
Corresponding Affymetrix probe sets: 10581917 (MoGene1.0st)   1456602_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034429
Ensembl peptide - ENSMUSP00000148428
NCBI entrez gene - 234740     See in Manteia.
MGI - MGI:2685024
RefSeq - XM_011248363
RefSeq - NM_001033321
RefSeq - NM_001357348
RefSeq - XM_006530926
RefSeq - XM_011248362
RefSeq Peptide - NP_001028493
RefSeq Peptide - NP_001344277
swissprot - Q3U284
swissprot - A0A1D5RLM3
Ensembl - ENSMUSG00000031951
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7T316ENSDARG00000042272Danio rerio
 F1NNL1ENSGALG00000003219Gallus gallus
 AC009163.2ENSG00000260092Homo sapiens
 Q9H6L2ENSG00000205084Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019306  Transmembrane protein 231


Gene Ontology (GO)
anatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structure developmentcell communicationcellular response to stimuluscellular component organizationmacromolecule localizationcellular component biogenesiscellular developmental processanatomical structureanatomical structure developmentcell communicationcell communicationcellular response tocellular response to stimuluscellular component ocellular component organizationmacromolecule localimacromolecule localizationcellular component bcellular component biogenesiscellular developmentcellular developmental process
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellmembraneorganelleprotein-containing complexcellcellmembranemembraneorganelleorganelleprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060563 neuroepithelial cell differentiation IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035869 ciliary transition zone IDA
 cellular_componentGO:0036038 MKS complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
limbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenotypevision/eye phenotypecardiovascular system phenotypenervous system phenotypeembryogenesis phenotypemortality/aginglimbs/digits/tail phenolimbs/digits/tail phenotypevision/eye phenotypevision/eye phenotypecardiovascular system pcardiovascular system phenotypenervous system phenotypnervous system phenotypeembryogenesis phenotypeembryogenesis phenotypemortality/agingmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: B9d1tm1d(EUCOMM)Wtsi/B9d1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: B9d1tm1d(EUCOMM)Wtsi/B9d1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B9d1tm1d(EUCOMM)Wtsi/B9d1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B9d1tm1d(EUCOMM)Wtsi/B9d1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B9d1tm1d(EUCOMM)Wtsi/B9d1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: B9d1tm1d(EUCOMM)Wtsi/B9d1tm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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