ENSMUSG00000032328


Mus musculus

Features
Gene ID: ENSMUSG00000032328
  
Biological name :Tmem30a
  
Synonyms : Q8VEK0 / Tmem30a / transmembrane protein 30A
  
Possible biological names infered from orthology : Q9NV96
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E1
Gene start: 79768943
Gene end: 79793507
  
Corresponding Affymetrix probe sets: 10595288 (MoGene1.0st)   1416446_at (Mouse Genome 430 2.0 Array)   1416447_at (Mouse Genome 430 2.0 Array)   1443619_at (Mouse Genome 430 2.0 Array)   1448339_at (Mouse Genome 430 2.0 Array)   1448340_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114042
Ensembl peptide - ENSMUSP00000034878
NCBI entrez gene - 69981     See in Manteia.
MGI - MGI:106402
RefSeq - NM_133718
RefSeq Peptide - NP_598479
swissprot - D3YVV1
swissprot - Q8VEK0
Ensembl - ENSMUSG00000032328
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem30aaENSDARG00000030236Danio rerio
 tmem30abENSDARG00000043555Danio rerio
 TMEM30AENSGALG00000015904Gallus gallus
 Q9NV96ENSG00000112697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BHG3 / Tmem30b / transmembrane protein 30B / Q3MIR4*ENSMUSG0000003443552
Q9D4D7 / Tmem30c / transmembrane protein 30CENSMUSG0000002275340


Protein motifs (from Interpro)
Interpro ID Name
 IPR005045  CDC50/LEM3 family
 IPR030351  Cell cycle control protein 50A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0015917 aminophospholipid transport IEA
 biological_processGO:0036010 protein localization to endosome IEA
 biological_processGO:0045332 phospholipid translocation IEA
 biological_processGO:0070863 positive regulation of protein exit from endoplasmic reticulum IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015247 aminophospholipid transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011584 increased alkaline phosphatase activity "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

 MP:0020211 slow movement "decreased rate or speed of the coordinated movements executed with a purpose" [GOC:NV]
Show

Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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