MP:0001391 | abnormal tail movements | "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg
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MP:0001819 | abnormal immune cell physiology | "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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MP:0002376 | abnormal dendritic cell physiology | "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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MP:0002418 | increased susceptibility to viral infection | "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Mb21d1tm1d(EUCOMM)Hmgu/Mb21d1tm1d(EUCOMM)Hmgu Genetic Background: involves: BALB/c * C57BL/6JJcl * C57BL/6N
Allelic Composition: Mb21d1tm1a(EUCOMM)Hmgu/Mb21d1tm1a(EUCOMM)Hmgu,Trex1tm1Tld/Trex1tm1Tld Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
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MP:0002451 | abnormal macrophage physiology | "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg
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MP:0008555 | abnormal interferon secretion | "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440] |
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Allelic Composition: Aim2Gt(CSG445)Byg/Aim2Gt(CSG445)Byg Genetic Background: B6.129P2-Aim2Gt(CSG445)Byg/J
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MP:0008574 | decreased circulating interferon-alpha level | "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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MP:0008576 | decreased circulating interferon-beta level | "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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MP:0008769 | abnormal plasmacytoid dendritic cell physiology | "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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MP:0009791 | increased susceptibility to viral infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Mb21d1tm1d(EUCOMM)Hmgu/Mb21d1tm1d(EUCOMM)Hmgu Genetic Background: involves: BALB/c * C57BL/6JJcl * C57BL/6N
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MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg
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