ENSMUSG00000032348


Mus musculus

Features
Gene ID: ENSMUSG00000032348
  
Biological name :Gsta4
  
Synonyms : Glutathione S-transferase A4 / Gsta4 / P24472
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E1
Gene start: 78182774
Gene end: 78209349
  
Corresponding Affymetrix probe sets: 10587315 (MoGene1.0st)   1416368_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149763
Ensembl peptide - ENSMUSP00000034903
NCBI entrez gene - 14860     See in Manteia.
MGI - MGI:1309515
RefSeq - NM_010357
RefSeq Peptide - NP_034487
swissprot - A0A1L1SS61
swissprot - P24472
Ensembl - ENSMUSG00000032348
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsta.1ENSDARG00000090228Danio rerio
 gsta.1ENSDARG00000113274Danio rerio
 gsta.2ENSDARG00000039832Danio rerio
 GSTAL3ENSGALG00000016322Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsta2 / P10648 / Glutathione S-transferase A2 / GSTA5* / GSTA3* / GSTA1* / Q7RTV2* / P08263* / P09210* / Q16772* / glutathione S-transferase alpha 1* / glutathione S-transferase alpha 5* /...ENSMUSG0000005793360
Gsta3 / P30115 / Glutathione S-transferase A3 ENSMUSG0000002593459
Gm10639 / GSTA2* / GSTA1* / GSTA3* / GSTA5* / P09210* / Q16772* / Q7RTV2* / P08263* / glutathione S-transferase alpha 2* / glutathione S-transferase alpha 1* / glutathione S-transferase alp...ENSMUSG0000007417959
Gsta1 / P13745 / Glutathione S-transferase A1 Glutathione S-transferase A1, N-terminally processed / GSTA2* / GSTA3* / GSTA5* / P09210* / Q16772* / Q7RTV2* / P08263* / glutathione S-transfe...ENSMUSG0000007418359
Gm3776 / predicted gene 3776 / GSTA2* / GSTA1* / GSTA3* / GSTA5* / P09210* / Q16772* / Q7RTV2* / P08263* / glutathione S-transferase alpha 1* / glutathione S-transferase alpha 5* / glutathi...ENSMUSG0000011170959
Hpgds / Q9JHF7 / Hematopoietic prostaglandin D synthase / O60760*ENSMUSG0000002991923


Protein motifs (from Interpro)
Interpro ID Name
 IPR003080  Glutathione S-transferase, alpha class
 IPR004045  Glutathione S-transferase, N-terminal
 IPR004046  Glutathione S-transferase, C-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process ISS
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009635 response to herbicide IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0004364 glutathione transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043295 glutathione binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kltm1Lex/Kltm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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