ENSMUSG00000032355


Mus musculus

Features
Gene ID: ENSMUSG00000032355
  
Biological name :Mlip
  
Synonyms : Mlip / Muscular LMNA-interacting protein / Q5FW52
  
Possible biological names infered from orthology : Q5VWP3
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 77102081
Gene end: 77352969
  
Corresponding Affymetrix probe sets: 10595094 (MoGene1.0st)   1430806_at (Mouse Genome 430 2.0 Array)   1453059_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139362
Ensembl peptide - ENSMUSP00000139251
Ensembl peptide - ENSMUSP00000139353
Ensembl peptide - ENSMUSP00000034910
Ensembl peptide - ENSMUSP00000138864
Ensembl peptide - ENSMUSP00000138938
Ensembl peptide - ENSMUSP00000139002
Ensembl peptide - ENSMUSP00000139055
Ensembl peptide - ENSMUSP00000139109
Ensembl peptide - ENSMUSP00000139188
Ensembl peptide - ENSMUSP00000139242
NCBI entrez gene - 69642     See in Manteia.
MGI - MGI:1916892
RefSeq - XM_017313586
RefSeq - NM_027150
RefSeq - XM_017313573
RefSeq - XM_017313574
RefSeq - XM_017313575
RefSeq - XM_017313577
RefSeq - XM_017313578
RefSeq - XM_017313579
RefSeq - XM_017313580
RefSeq - XM_017313581
RefSeq - XM_017313582
RefSeq - XM_017313584
RefSeq - XM_017313585
RefSeq - XM_006511410
RefSeq - XM_006511411
RefSeq - XM_006511412
RefSeq - XM_006511413
RefSeq - XM_006511414
RefSeq - XM_006511415
RefSeq - XM_006511416
RefSeq - XM_006511417
RefSeq - XM_006511418
RefSeq - XM_006511420
RefSeq - XM_006511421
RefSeq - XM_006511423
RefSeq - XM_006511424
RefSeq - XM_006511425
RefSeq - XM_006511426
RefSeq - XM_006511427
RefSeq - XM_017313568
RefSeq - XM_017313569
RefSeq - XM_017313570
RefSeq - XM_017313571
RefSeq - XM_017313572
RefSeq Peptide - NP_081426
swissprot - Q5FW52
swissprot - V9GWW6
swissprot - V9GX17
swissprot - V9GX62
swissprot - V9GXA0
swissprot - V9GXK2
swissprot - V9GXP3
swissprot - V9GXW5
swissprot - V9GXX2
swissprot - B7ZMP8
Ensembl - ENSMUSG00000032355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlipENSDARG00000089920Danio rerio
 MLIPENSGALG00000016301Gallus gallus
 MLIPENSG00000146147Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029331  Muscular LMNA-interacting protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IDA
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0031981 nuclear lumen IDA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IGI
 molecular_functionGO:0005521 lamin binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mlip+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Lmnatm1Stw/Lmna+,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmnatm1Stw/Lmna+,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Lmnatm1Stw/Lmna+,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr