ENSMUSG00000032769


Mus musculus

Features
Gene ID: ENSMUSG00000032769
  
Biological name :Trpa1
  
Synonyms : Q8BLA8 / Transient receptor potential cation channel subfamily A member 1 / Trpa1
  
Possible biological names infered from orthology : O75762
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A3
Gene start: 14872648
Gene end: 14918862
  
Corresponding Affymetrix probe sets: 10353221 (MoGene1.0st)   1457164_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043594
NCBI entrez gene - 277328     See in Manteia.
MGI - MGI:3522699
RefSeq - NM_177781
RefSeq - XM_006495526
RefSeq Peptide - NP_808449
swissprot - Q8BLA8
Ensembl - ENSMUSG00000032769
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpa1aENSDARG00000016699Danio rerio
 trpa1bENSDARG00000031875Danio rerio
 TRPA1ENSGALG00000034751Gallus gallus
 TRPA1ENSG00000104321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UMR0 / Ankrd27 / Ankyrin repeat domain-containing protein 27 / Q96NW4* / ankyrin repeat domain 27*ENSMUSG0000003486712


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR005821  Ion transport domain
 IPR020683  Ankyrin repeat-containing domain
 IPR030288  Transient receptor potential cation channel subfamily A member 1
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0009409 response to cold IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IMP
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050955 thermoception IDA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IMP
 biological_processGO:0050968 detection of chemical stimulus involved in sensory perception of pain IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0032421 stereocilium bundle IDA
 molecular_functionGO:0005216 ion channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015267 channel activity IDA
 molecular_functionGO:0015278 calcium-release channel activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097604 temperature-gated cation channel activity IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001986 taste sensitivity/ preferences 
Show

Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

 MP:0002330 abnormal bronchial provocation "anomaly in the results of measures of responsiveness to allergens, pharmacological solutions, or control solutions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe-10J/Ap3b1pe-10J
Genetic Background: C57BL/6J-Ap3b1pe-10J

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Trpa1tm1Jul/Trpa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003663 abnormal thermosensation "defect in the ability to sense or display a preference for a given temperature" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96549]
Show

Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Ap3b1pe-10J/Ap3b1pe-10J
Genetic Background: C57BL/6J-Ap3b1pe-10J

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpa1tm1Jul/Trpa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe-10J/Ap3b1pe-10J
Genetic Background: C57BL/6J-Ap3b1pe-10J

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ap3b1pe-10J/Ap3b1pe-10J
Genetic Background: C57BL/6J-Ap3b1pe-10J

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Lama5tm1Jhm/Lama5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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