ENSMUSG00000032867


Mus musculus

Features
Gene ID: ENSMUSG00000032867
  
Biological name :Fbxw8
  
Synonyms : F-box/WD repeat-containing protein 8 / Fbxw8 / Q8BIA4
  
Possible biological names infered from orthology : F-box and WD repeat domain containing 8 / Q8N3Y1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 118064965
Gene end: 118155464
  
Corresponding Affymetrix probe sets: 10533095 (MoGene1.0st)   1426944_at (Mouse Genome 430 2.0 Array)   1436732_s_at (Mouse Genome 430 2.0 Array)   1458413_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047012
NCBI entrez gene - 231672     See in Manteia.
MGI - MGI:1923041
RefSeq - NM_172721
RefSeq Peptide - NP_766309
swissprot - Q8BIA4
Ensembl - ENSMUSG00000032867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw8ENSDARG00000079089Danio rerio
 FBXW8ENSGALG00000008207Gallus gallus
 FBXW8ENSG00000174989Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IC
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0060712 spongiotrophoblast layer development IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IPI
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:1990393 3M complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itsn1tm2.1Mapr/Itsn1tm2.1Mapr
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itsn1tm2.1Mapr/Itsn1tm2.1Mapr
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Itsn1tm2.1Mapr/Itsn1tm2.1Mapr
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Itsn1tm2.1Mapr/Itsn1tm2.1Mapr
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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