ENSMUSG00000032908


Mus musculus

Features
Gene ID: ENSMUSG00000032908
  
Biological name :Sgpp2
  
Synonyms : Q810K3 / Sgpp2 / Sphingosine-1-phosphate phosphatase 2
  
Possible biological names infered from orthology : Q8IWX5
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 78310345
Gene end: 78420289
  
Corresponding Affymetrix probe sets: 10347734 (MoGene1.0st)   1457867_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036656
NCBI entrez gene - 433323     See in Manteia.
MGI - MGI:3589109
RefSeq - XM_017321596
RefSeq - NM_001004173
RefSeq - XM_006496506
RefSeq - XM_011238695
RefSeq Peptide - NP_001004173
swissprot - Q810K3
Ensembl - ENSMUSG00000032908
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SGPP2ENSDARG00000079608Danio rerio
 SGPP2ENSGALG00000005245Gallus gallus
 SGPP2ENSG00000163082Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgpp1 / Q9JI99 / sphingosine-1-phosphate phosphatase 1 / Q9BX95*ENSMUSG0000002105440


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006670 sphingosine metabolic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042392 sphingosine-1-phosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0012232 abnormal ceramide level 
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Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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