ENSMUSG00000033156


Mus musculus

Features
Gene ID: ENSMUSG00000033156
  
Biological name :Cst10
  
Synonyms : Cst10 / Cystatin 10 / Q9JM84
  
Possible biological names infered from orthology : CST1 / CST2 / CST4 / CST5 / cystatin D / cystatin S / cystatin SA / cystatin SN / P01036 / P01037 / P09228 / P28325
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 149405057
Gene end: 149410293
  
Corresponding Affymetrix probe sets: 10476931 (MoGene1.0st)   1449447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043520
Ensembl peptide - ENSMUSP00000105564
Ensembl peptide - ENSMUSP00000105565
NCBI entrez gene - 58214     See in Manteia.
MGI - MGI:1930004
RefSeq - NM_021405
RefSeq Peptide - NP_067380
swissprot - Q9JM84
Ensembl - ENSMUSG00000033156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cst3ENSDARG00000007795Danio rerio
 zgc:163030ENSDARG00000069192Danio rerio
 CST3ENSGALG00000028520Gallus gallus
 CST1ENSG00000170373Homo sapiens
 CST2ENSG00000170369Homo sapiens
 CST4ENSG00000101441Homo sapiens
 CST5ENSG00000170367Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cst3 / P21460 / Cystatin-C / P01034*ENSMUSG0000002744739
Cst6 / cystatin E/M / Q15828*ENSMUSG0000002484630
Cst7 / O89098 / Cystatin-F / O76096*ENSMUSG0000006812928


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR001713  Proteinase inhibitor I25A, stefin
 IPR018073  Proteinase inhibitor I25, cystatin, conserved site
 IPR027214  Cystatin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002062 chondrocyte differentiation IDA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0048469 cell maturation IDA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
Show

Allelic Composition: Mc3rtm1Cone/Mc3r+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc3rtm1Cone/Mc3r+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc3rtm1Cone/Mc3r+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cst10tm1Hkaw/Cst10tm1Hkaw,Enpp1ttw/Enpp1ttw
Genetic Background: involves: C57BL/6 * ICR

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc3rtm1Cone/Mc3r+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc3rtm1Cone/Mc3r+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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