Manteia

ENSMUSG00000033257

Mus musculus

Features

Gene ID:	ENSMUSG00000033257

Biological name :	Ttll4

Synonyms :	Q80UG8 / Ttll4 / tubulin tyrosine ligase-like family, member 4

Possible biological names infered from orthology :	Q14679 / tubulin tyrosine ligase like 4

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	C4
Gene start:	74661745
Gene end:	74703730

Corresponding Affymetrix probe sets:	10347460 (MoGene1.0st) 1428911_at (Mouse Genome 430 2.0 Array) 1428912_at (Mouse Genome 430 2.0 Array) 1436249_at (Mouse Genome 430 2.0 Array) 1459031_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000037406 Ensembl peptide - ENSMUSP00000119964 Ensembl peptide - ENSMUSP00000116733 Ensembl peptide - ENSMUSP00000109308 NCBI entrez gene - 67534 See in Manteia. MGI - MGI:1914784 RefSeq - XM_006496225 RefSeq - NM_001014974 RefSeq - XM_006496224 RefSeq Peptide - NP_001014974 swissprot - D3Z7H1 swissprot - Q80UG8 swissprot - D3YY08 swissprot - D3Z402 Ensembl - ENSMUSG00000033257

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ttll5 / Q8CHB8 / tubulin tyrosine ligase-like family, member 5 / Q6EMB2* / tubulin tyrosine ligase like 5*	ENSMUSG00000012609	18
Ttll6 / A4Q9E8 / tubulin tyrosine ligase-like family, member 6 / Q8N841* / tubulin tyrosine ligase like 6*	ENSMUSG00000038756	14
Ttll7 / tubulin tyrosine ligase-like family, member 7 / Q6ZT98* / tubulin tyrosine ligase like 7*	ENSMUSG00000036745	13
A4Q9F4 / Ttll11 / tubulin tyrosine ligase-like family, member 11 / Q8NHH1* / tubulin tyrosine ligase like 11*	ENSMUSG00000026885	12
Ttll13 / A4Q9F6 / tubulin tyrosine ligase-like family, member 13 / A6NNM8* / TTLL13P* / tubulin tyrosine ligase like 13, pseudogene*	ENSMUSG00000045467	12
Ttll2 / A4Q9E4 / tubulin tyrosine ligase-like family, member 2 / Q9BWV7* / tubulin tyrosine ligase like 2*	ENSMUSG00000079722	12
Ttll1 / Q91V51 / tubulin tyrosine ligase-like 1 / O95922*	ENSMUSG00000022442	9
Ttll10 / tubulin tyrosine ligase-like family, member 10 / Q6ZVT0* / tubulin tyrosine ligase like 10*	ENSMUSG00000029074	9
Ttll3 / A4Q9E5 / tubulin tyrosine ligase-like family, member 3 / Q9Y4R7* / ARPC4-TTLL3* / ARPC4-TTLL3 readthrough* / tubulin tyrosine ligase like 3*	ENSMUSG00000030276	9
Ttll9 / A2APC3 / tubulin tyrosine ligase-like family, member 9 / Q3SXZ7* / tubulin tyrosine ligase like 9*	ENSMUSG00000074673	9
Ttll8 / A4Q9F1 / tubulin tyrosine ligase-like family, member 8 / A6PVC2* / tubulin tyrosine ligase like 8*	ENSMUSG00000022388	8

Protein motifs (from Interpro)

Interpro ID	Name
IPR004344	Tubulin-tyrosine ligase/Tubulin polyglutamylase
IPR027748	Tubulin polyglutamylase TTLL-4

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006464	cellular protein modification process	IEA
biological_process	GO:0018095	protein polyglutamylation	IEA
biological_process	GO:0018200	peptidyl-glutamic acid modification	IDA
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005874	microtubule	IEA
cellular_component	GO:0005929	cilium	IEA
cellular_component	GO:0042995	cell projection	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0015631	tubulin binding	IDA
molecular_function	GO:0016874	ligase activity	IEA
molecular_function	GO:0070739	protein-glutamic acid ligase activity	IDA

Pathways (from Reactome)

Pathway description

Carboxyterminal post-translational modifications of tubulin

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Kmt5b^{tm1a(KOMP)Wtsi}/Kmt5b^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Kmt5b^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kmt5b^{tm1a(KOMP)Wtsi}/Kmt5b^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Kmt5b^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001413	abnormal response to new environment	"altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Kmt5b^{tm1a(KOMP)Wtsi}/Kmt5b^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Kmt5b^{tm1a(KOMP)Wtsi}/Wtsi
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt5b^{tm1a(KOMP)Wtsi}/Kmt5b^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Kmt5b^{tm1a(KOMP)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr