ENSMUSG00000033498


Mus musculus

Features
Gene ID: ENSMUSG00000033498
  
Biological name :Strc
  
Synonyms : Q8VIM6 / Stereocilin / Strc
  
Possible biological names infered from orthology : Q7RTU9
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 121363728
Gene end: 121387168
  
Corresponding Affymetrix probe sets: 10486789 (MoGene1.0st)   1421695_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039378
Ensembl peptide - ENSMUSP00000118211
NCBI entrez gene - 140476     See in Manteia.
MGI - MGI:2153816
RefSeq - NM_080459
RefSeq - XM_006498734
RefSeq Peptide - NP_536707
swissprot - F6UNX5
swissprot - Q8VIM6
Ensembl - ENSMUSG00000033498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:cabz01059983.1ENSDARG00000105391Danio rerio
 STRCENSG00000242866Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otoa / Q8K561 / Otoancorin / Q7RTW8*ENSMUSG0000003499012


Protein motifs (from Interpro)
Interpro ID Name
 IPR026061  Stereocilin
 IPR026664  Stereocilin-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IBA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0032426 stereocilium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060091 kinocilium IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004412 abnormal cochlear microphonics "anomalous bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; the cochlear microphonic (CM) is an electric response dominated by OHC receptor potentials from the basal turn of the cochlea and provides a measure of transducer function in OHCs; in an active ear, CM waveforms show post-stimulus ringing (i.e. a cochlear echo) whereas in a passive ear system, CM decays at the cessation of the tone burst" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr6a1tm1Coo/Nr6a1tm1Coo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr6a1tm1Coo/Nr6a1tm1Coo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr6a1tm1Coo/Nr6a1tm1Coo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr6a1tm1Coo/Nr6a1tm1Coo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006335 abnormal hearing electrophysiology "anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr6a1tm1Coo/Nr6a1tm1Coo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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