ENSMUSG00000033740


Mus musculus

Features
Gene ID: ENSMUSG00000033740
  
Biological name :St18
  
Synonyms : Q80TY4 / St18 / suppression of tumorigenicity 18
  
Possible biological names infered from orthology : O60284 / ST18, C2H2C-type zinc finger
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A1
Gene start: 6487231
Gene end: 6860940
  
Corresponding Affymetrix probe sets: 10344679 (MoGene1.0st)   1436793_at (Mouse Genome 430 2.0 Array)   1455123_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122055
Ensembl peptide - ENSMUSP00000120298
Ensembl peptide - ENSMUSP00000131417
Ensembl peptide - ENSMUSP00000142317
Ensembl peptide - ENSMUSP00000142063
Ensembl peptide - ENSMUSP00000141266
Ensembl peptide - ENSMUSP00000042056
Ensembl peptide - ENSMUSP00000117789
Ensembl peptide - ENSMUSP00000118129
Ensembl peptide - ENSMUSP00000118322
Ensembl peptide - ENSMUSP00000120134
NCBI entrez gene - 240690     See in Manteia.
MGI - MGI:2446700
RefSeq - XM_011238375
RefSeq - XM_006495501
RefSeq - XM_006495502
RefSeq - XM_006495503
RefSeq - XM_006495504
RefSeq - XM_011238369
RefSeq - XM_011238370
RefSeq - XM_011238371
RefSeq - XM_011238372
RefSeq - XM_011238373
RefSeq - XM_011238374
RefSeq - NM_001244692
RefSeq - NM_001244693
RefSeq - NM_173868
RefSeq Peptide - NP_001231621
RefSeq Peptide - NP_001231622
RefSeq Peptide - NP_776293
swissprot - A0A0A6YXN3
swissprot - Q148A0
swissprot - D3YZ65
swissprot - A0A0A6YVU2
swissprot - Q80TY4
swissprot - D3YUH3
swissprot - A0A0A6YY81
Ensembl - ENSMUSG00000033740
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ST18ENSGALG00000015254Gallus gallus
 ST18ENSG00000147488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myt1l / P97500 / Myelin transcription factor 1-like protein / Q9UL68* / myelin transcription factor 1 like*ENSMUSG0000006191146
Myt1 / Q8CFC2 / Myelin transcription factor 1 / Q01538*ENSMUSG0000001050545


Protein motifs (from Interpro)
Interpro ID Name
 IPR002515  Zinc finger, C2HC-type
 IPR013681  Myelin transcription factor 1
 IPR036060  Zinc finger, C2HC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0070102 interleukin-6-mediated signaling pathway ISO
 biological_processGO:0070498 interleukin-1-mediated signaling pathway ISO
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0032993 protein-DNA complex ISO
 molecular_functionGO:0001047 core promoter binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr