ENSMUSG00000034028


Mus musculus

Features
Gene ID: ENSMUSG00000034028
  
Biological name :Cd226
  
Synonyms : Cd226 / CD226 antigen / Q8K4F0
  
Possible biological names infered from orthology : CD226 molecule / Q15762
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E4
Gene start: 89197431
Gene end: 89270201
  
Corresponding Affymetrix probe sets: 10457168 (MoGene1.0st)   1445388_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043551
Ensembl peptide - ENSMUSP00000095104
NCBI entrez gene - 225825     See in Manteia.
MGI - MGI:3039602
RefSeq - XM_017317894
RefSeq - NM_001039149
RefSeq - NM_178687
RefSeq - XM_006526461
RefSeq - XM_006526462
RefSeq - XM_006526463
RefSeq - XM_006526464
RefSeq Peptide - NP_001034238
RefSeq Peptide - NP_848802
swissprot - Q5DW69
swissprot - Q8K4E3
swissprot - Q8K4F0
Ensembl - ENSMUSG00000034028
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd226ENSDARG00000045391Danio rerio
 CD226ENSGALG00000013748Gallus gallus
 CD226ENSG00000150637Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0002729 positive regulation of natural killer cell cytokine production IMP
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
 biological_processGO:0002891 positive regulation of immunoglobulin mediated immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0033005 positive regulation of mast cell activation IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IEA
 biological_processGO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Patz1tm1.1Welm/Patz1tm1.1Welm,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Capn3tm1Jsb/Capn3+,Ttntm1.1Isrd/Ttntm1.1Isrd
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Patz1tm1.1Welm/Patz1tm1.1Welm,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Capn3tm1Jsb/Capn3+,Ttntm1.1Isrd/Ttntm1.1Isrd
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Patz1tm1.1Welm/Patz1tm1.1Welm,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd226tm1Shib/Cd226tm1Shib
Genetic Background: involves: BALB/c

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Patz1tm1.1Welm/Patz1tm1.1Welm,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd226tm1Shib/Cd226tm1Shib
Genetic Background: involves: BALB/c

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Patz1tm1.1Welm/Patz1tm1.1Welm,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd226tm1Shib/Cd226tm1Shib
Genetic Background: involves: BALB/c

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Patz1tm1.1Welm/Patz1tm1.1Welm,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd226tm1.1Cln/Cd226tm1.1Cln,Tg(TcraTcrb)1100Mjb/0
Genetic Background: B6.Cg-Cd226tm1.1Cln Tg(TcraTcrb)1100Mjb

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cd226tm1.1Cln/Cd226tm1.1Cln,Tg(TcraTcrb)1100Mjb/0
Genetic Background: B6.Cg-Cd226tm1.1Cln Tg(TcraTcrb)1100Mjb

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd226tm1Shib/Cd226tm1Shib
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062300 P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*  / complex / reaction
 ENSMUSG00000040511 Pvr / poliovirus receptor / P15151*  / complex / reaction






 

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