ENSMUSG00000034139


Mus musculus

Features
Gene ID: ENSMUSG00000034139
  
Biological name :Serpini2
  
Synonyms : Q9JK88 / serine (or cysteine) peptidase inhibitor, clade I, member 2 / Serpini2
  
Possible biological names infered from orthology : O75830 / serpin family I member 2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 75242370
Gene end: 75270078
  
Corresponding Affymetrix probe sets: 10498741 (MoGene1.0st)   1425152_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046943
NCBI entrez gene - 67931     See in Manteia.
MGI - MGI:1915181
RefSeq - NM_026460
RefSeq Peptide - NP_080736
swissprot - Q4G0D3
swissprot - Q9JK88
Ensembl - ENSMUSG00000034139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O75830ENSG00000114204Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35684 / Serpini1 / serine (or cysteine) peptidase inhibitor, clade I, member 1 / Q99574* / serpin family I member 1*ENSMUSG0000002783436
Q07235 / Serpine2 / serine (or cysteine) peptidase inhibitor, clade E, member 2 / P07093* / serpin family E member 2*ENSMUSG0000002624931
P32261 / Serpinc1 / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 / P01008* / serpin family C member 1*ENSMUSG0000002671531
Q9CQV3 / Serpinb11 / Serpin B11 / Q96P15* / serpin family B member 11 (gene/pseudogene)*ENSMUSG0000002632730
Q9D7P9 / Serpinb12 / Serpin B12 / Q96P63* / serpin family B member 12*ENSMUSG0000005995630
Serpine1 / serine (or cysteine) peptidase inhibitor, clade E, member 1 / P05121* / serpin family E member 1*ENSMUSG0000003741129
Q9D695 / Serpinb7 / Serpin B7 / O75635* / serpin family B member 7*ENSMUSG0000006700129
P19324 / Serpinh1 / Serpin H1 / P50454* / serpin family H member 1*ENSMUSG0000007043625
Serpine3 / serpin family E member 3 / A8MV23*ENSMUSG0000009115523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003335 exocrine pancreatic insufficiency "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009160 abnormal pancreatic acinar cell zymogen granule "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbs1tm1Vcs/Bbs1tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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