ENSMUSG00000034171


Mus musculus

Features
Gene ID: ENSMUSG00000034171
  
Biological name :Faah
  
Synonyms : Faah / Fatty-acid amide hydrolase 1 / O08914
  
Possible biological names infered from orthology : fatty acid amide hydrolase / O00519
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 115967145
Gene end: 116017926
  
Corresponding Affymetrix probe sets: 10515220 (MoGene1.0st)   1421969_a_at (Mouse Genome 430 2.0 Array)   1434091_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041543
NCBI entrez gene - 14073     See in Manteia.
MGI - MGI:109609
RefSeq - NM_010173
RefSeq - XM_017319974
RefSeq Peptide - NP_034303
swissprot - O08914
Ensembl - ENSMUSG00000034171
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 faahENSDARG00000077764Danio rerio
 FAAHENSGALG00000010433Gallus gallus
 FAAHENSG00000117480Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000120  Amidase
 IPR020556  Amidase, conserved site
 IPR023631  Amidase signature domain
 IPR030560  Fatty-acid amide hydrolase 1
 IPR036928  Amidase signature (AS) superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009062 fatty acid catabolic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane ISS
 molecular_functionGO:0004040 amidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017064 fatty acid amide hydrolase activity ISO
 molecular_functionGO:0047372 acylglycerol lipase activity IMP
 molecular_functionGO:0102077 oleamide hydrolase activity IEA
 molecular_functionGO:0103073 anandamide amidohydrolase activity IEA


Pathways (from Reactome)
Pathway description
Arachidonic acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Faahtm1.1Flee/Faah+
Genetic Background: B6.Cg-Faahtm1.1Flee

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1Map/Cnr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Faahtm1.1Flee/Faah+
Genetic Background: B6.Cg-Faahtm1.1Flee

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Faahtm1Crv/Faahtm1Crv
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001981 enhanced chemically-elicited antinociception "greater than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Faahtm1Crv/Faahtm1Crv
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001987 alcohol preference 
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1Map/Cnr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1Map/Cnr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Faahtm1.1Flee/Faah+
Genetic Background: B6.Cg-Faahtm1.1Flee

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Faahtm1Crv/Faahtm1Crv
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002863 improved righting response "faster ability or less amount of time needed to recover from supine position" [J:86936]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0004166 abnormal limbic system morphology "any malformation or absence of any of a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory; these structures act together to control the endocrine system and the autonomic nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Faahtm1Crv/Faahtm1Crv
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faahtm1Crv/Faahtm1Crv
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012319 fast extinction of fear memory "enhanced ability to extinguish aversive memories associated with a traumatic incident" [http://www.mpipsykl.mpg.de/en/research/themes/depression/wotjak_02/]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Faahtm1.1Flee/Faah+
Genetic Background: B6.Cg-Faahtm1.1Flee

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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