ENSMUSG00000034175


Mus musculus

Features
Gene ID: ENSMUSG00000034175
  
Biological name :Rhbdd3
  
Synonyms : Q8BP97 / Rhbdd3 / rhomboid domain containing 3
  
Possible biological names infered from orthology : Q9Y3P4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 5098926
Gene end: 5106093
  
Corresponding Affymetrix probe sets: 10374020 (MoGene1.0st)   1433760_a_at (Mouse Genome 430 2.0 Array)   1438548_x_at (Mouse Genome 430 2.0 Array)   1454719_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120264
Ensembl peptide - ENSMUSP00000118085
Ensembl peptide - ENSMUSP00000119972
Ensembl peptide - ENSMUSP00000044703
Ensembl peptide - ENSMUSP00000099131
Ensembl peptide - ENSMUSP00000105504
Ensembl peptide - ENSMUSP00000116703
NCBI entrez gene - 279766     See in Manteia.
MGI - MGI:2444684
RefSeq - NM_177370
RefSeq - NM_001290491
RefSeq - NM_001290492
RefSeq - NM_001290493
RefSeq - XM_006514714
RefSeq - XM_006514715
RefSeq - XM_017314584
RefSeq Peptide - NP_001277422
RefSeq Peptide - NP_796344
RefSeq Peptide - NP_001277420
RefSeq Peptide - NP_001277421
swissprot - Q5SUU0
swissprot - Q8BP97
swissprot - Z4YMS1
swissprot - B7ZNJ8
swissprot - Q5SUT8
swissprot - Q5SUT9
Ensembl - ENSMUSG00000034175
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhbdd3ENSDARG00000079816Danio rerio
 Q9Y3P4ENSG00000100263Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR022764  Peptidase S54, rhomboid domain
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0001889 liver development IMP
 biological_processGO:0002673 regulation of acute inflammatory response IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0009410 response to xenobiotic stimulus IMP
 biological_processGO:0032815 negative regulation of natural killer cell activation IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0050708 regulation of protein secretion IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0003080 competent NK cell cytolysis "ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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