ENSMUSG00000034247


Mus musculus

Features
Gene ID: ENSMUSG00000034247
  
Biological name :Plekhm1
  
Synonyms : Pleckstrin homology domain-containing family M member 1 / Plekhm1 / Q7TSI1
  
Possible biological names infered from orthology : pleckstrin homology and RUN domain containing M1 / Q9Y4G2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 103364275
Gene end: 103412687
  
Corresponding Affymetrix probe sets: 10391918 (MoGene1.0st)   1454746_at (Mouse Genome 430 2.0 Array)   1457195_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047327
Ensembl peptide - ENSMUSP00000138878
NCBI entrez gene - 353047     See in Manteia.
MGI - MGI:2443207
RefSeq - NM_183034
RefSeq Peptide - NP_898855
swissprot - Q7TSI1
swissprot - V9GWX7
Ensembl - ENSMUSG00000034247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekhm1ENSDARG00000099954Danio rerio
 PLEKHM1ENSGALG00000000201Gallus gallus
 Q9Y4G2ENSG00000225190Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BM47 / Plekhm3 / Pleckstrin homology domain-containing family M member 3 / Q6ZWE6* / pleckstrin homology domain containing M3*ENSMUSG0000005134419
Rubcn / Q80U62 / Run domain Beclin-1-interacting and cysteine-rich domain-containing protein / Q92622* / RUN and cysteine rich domain containing beclin 1 interacting protein*ENSMUSG0000003562915
Def8 / Q99J78 / Differentially expressed in FDCP 8 / Q6ZN54* / differentially expressed in FDCP 8 homolog*ENSMUSG0000000148212
Rubcnl / RUN and cysteine rich domain containing beclin 1 interacting protein like / Q9H714*ENSMUSG0000003495911


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR004012  RUN domain
 IPR011993  PH-like domain superfamily
 IPR025258  Putative zinc-RING and/or ribbon
 IPR037213  RUN domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032418 lysosome localization IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:1900029 positive regulation of ruffle assembly IMP
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0003173 decreased lysosomal enzyme secretion "production of glycoprotein hydrolytic enzymes is decreased compared to normal" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0013631 decreased bone trabecular spacing "decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Hbatm1(HBA)Tow/Hbatm1(HBA)Tow,Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow,Slc12a4Rbc10/Slc12a4Rbc10
Genetic Background: involves: 129 * BALB/c * C57BL/6J

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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