ENSMUSG00000034401


Mus musculus

Features
Gene ID: ENSMUSG00000034401
  
Biological name :Spata6
  
Synonyms : Q3U6K5 / Spata6 / Spermatosis-associated protein 6
  
Possible biological names infered from orthology : Q9NWH7 / spermatogenesis associated 6
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 111719984
Gene end: 111829184
  
Corresponding Affymetrix probe sets: 10507040 (MoGene1.0st)   1418650_at (Mouse Genome 430 2.0 Array)   1418651_at (Mouse Genome 430 2.0 Array)   1438023_at (Mouse Genome 430 2.0 Array)   1445355_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081383
Ensembl peptide - ENSMUSP00000114610
Ensembl peptide - ENSMUSP00000036964
Ensembl peptide - ENSMUSP00000069435
NCBI entrez gene - 67946     See in Manteia.
MGI - MGI:1915196
RefSeq - XM_006503346
RefSeq - XM_006503347
RefSeq - XM_006503348
RefSeq - NM_026470
RefSeq Peptide - NP_080746
swissprot - Q3U6K5
swissprot - A2AED8
swissprot - A2AED9
Ensembl - ENSMUSG00000034401
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spata6ENSDARG00000021115Danio rerio
 SPATA6ENSGALG00000010502Gallus gallus
 Q9NWH7ENSG00000132122Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B2RV46 / 4430402I18Rik / RIKEN cDNA 4430402I18 gene / Q8N4H0* / SPATA6L* / spermatogenesis associated 6 like*ENSMUSG0000006420221


Protein motifs (from Interpro)
Interpro ID Name
 IPR027207  Spermatogenesis-associated protein 6
 IPR032732  Spermatogenesis-associated protein 6, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0044458 motile cilium assembly IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097224 sperm connecting piece IDA
 molecular_functionGO:0032027 myosin light chain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009234 absent sperm head "absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009830 abnormal sperm connecting piece morphology "any structural abnormality in the segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum" [PMID:14581499]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009833 absent sperm mitochondrial sheath "absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009834 abnormal sperm annulus morphology "any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009837 abnormal sperm end piece morphology "any structural abnormality in the short remaining region of the sperm flagellum, which contains only the axoneme surrounded by the plasma membrane" [PMID:14581499]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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