ENSMUSG00000034452


Mus musculus

Features
Gene ID: ENSMUSG00000034452
  
Biological name :Slc24a1
  
Synonyms : Slc24a1 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
  
Possible biological names infered from orthology : O60721 / solute carrier family 24 member 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 64922861
Gene end: 64951607
  
Corresponding Affymetrix probe sets: 10594490 (MoGene1.0st)   1451647_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035616
NCBI entrez gene - 214111     See in Manteia.
MGI - MGI:2384871
RefSeq - NM_144813
RefSeq - XM_017313271
RefSeq Peptide - NP_659062
swissprot - Q91WD8
Ensembl - ENSMUSG00000034452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc24a1ENSDARG00000041431Danio rerio
 SLC24A1ENSGALG00000007495Gallus gallus
 O60721ENSG00000074621Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc24a2 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 / Q9UI40* / solute carrier family 24 member 2*ENSMUSG0000003799632
Q99PD7 / Slc24a3 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 / Q9HC58* / solute carrier family 24 member 3*ENSMUSG0000006387320
Slc24a4 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 / Q8NFF2* / solute carrier family 24 member 4*ENSMUSG0000004177119
Q8C261 / Slc24a5 / solute carrier family 24, member 5 / Q71RS6*ENSMUSG0000003518315
Q925Q3 / Slc8b1 / solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 / Q6J4K2* / solute carrier family 8 member B1*ENSMUSG0000003275412


Protein motifs (from Interpro)
Interpro ID Name
 IPR004481  Sodium/potassium/calcium exchanger
 IPR004817  Sodium/potassium/calcium exchanger 1
 IPR004837  Sodium/calcium exchanger membrane region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IBA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060291 long-term synaptic potentiation IBA
 biological_processGO:0060292 long term synaptic depression IBA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0008273 calcium, potassium:sodium antiporter activity IBA
 molecular_functionGO:0030955 potassium ion binding IBA
 molecular_functionGO:0031402 sodium ion binding IBA


Pathways (from Reactome)
Pathway description
Sodium/Calcium exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0008144 nyctalopia "decreased ability to see clearly in reduced illumination; often due to a deficiency of vitamin A or to a retinal disorder" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", NCBI:matt "Matthew Mailman"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

 MP:0012034 abnormal a wave shape "any anomaly in the graphical representation of the a wave in the electroretinogram; the a wave represents the general physiological health of the photoreceptors in the outer retina" [http://webvision.med.utah.edu, MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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