ENSMUSG00000034485


Mus musculus

Features
Gene ID: ENSMUSG00000034485
  
Biological name :Uaca
  
Synonyms : Uaca / uveal autoantigen with coiled-coil domains and ankyrin repeats
  
Possible biological names infered from orthology : Q9BZF9
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 60794542
Gene end: 60880370
  
Corresponding Affymetrix probe sets: 10586017 (MoGene1.0st)   1452985_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150547
Ensembl peptide - ENSMUSP00000151172
Ensembl peptide - ENSMUSP00000062047
NCBI entrez gene - 72565     See in Manteia.
MGI - MGI:1919815
RefSeq - XM_017313609
RefSeq - NM_001357407
RefSeq - NM_001357408
RefSeq - NM_028283
RefSeq - XM_006511481
RefSeq - XM_006511482
RefSeq - XM_006511483
RefSeq Peptide - NP_001344337
RefSeq Peptide - NP_082559
RefSeq Peptide - NP_001344336
swissprot - A0A1L1SVG0
swissprot - A0A1L1STY4
swissprot - A0A0R4J0S7
Ensembl - ENSMUSG00000034485
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uacaaENSDARG00000069250Danio rerio
 uacabENSDARG00000060238Danio rerio
 ENSGALG00000034100Gallus gallus
 UACAENSG00000137831Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rai14 / Q9EP71 / Mus musculus retinoic acid induced 14 (Rai14), transcript variant 3, mRNA. / Q9P0K7* / retinoic acid induced 14*ENSMUSG0000002224624
Ankrd35 / ankyrin repeat domain 35 / Q8N283*ENSMUSG0000003835418
Q80VM7 / Ankrd24 / Ankyrin repeat domain-containing protein 24 / Q8TF21* / ankyrin repeat domain 24*ENSMUSG0000005470816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR030227  Protein Nucling
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002717 abnormal preputial gland morphology "anomalous structure of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Uacatm1Kiy/Uaca+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr