ENSMUSG00000034533


Mus musculus

Features
Gene ID: ENSMUSG00000034533
  
Biological name :Scn10a
  
Synonyms : Q6QIY3 / Scn10a / sodium channel, voltage-gated, type X, alpha
  
Possible biological names infered from orthology : Q9Y5Y9 / sodium voltage-gated channel alpha subunit 10
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 119608456
Gene end: 119719322
  
Corresponding Affymetrix probe sets: 10597686 (MoGene1.0st)   1450266_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081845
Ensembl peptide - ENSMUSP00000148987
Ensembl peptide - ENSMUSP00000150830
NCBI entrez gene - 20264     See in Manteia.
MGI - MGI:108029
RefSeq - XM_017313223
RefSeq - NM_001205321
RefSeq - NM_009134
RefSeq - XM_017313221
RefSeq - XM_017313222
RefSeq Peptide - NP_001192250
RefSeq Peptide - NP_033160
swissprot - Q6QIY3
swissprot - K3W4P8
Ensembl - ENSMUSG00000034533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn12aaENSDARG00000090724Danio rerio
 scn12abENSDARG00000102312Danio rerio
 Q9Y5Y9ENSG00000185313Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scn5a / Q9JJV9 / Sodium channel protein type 5 subunit alpha / Q14524* / sodium voltage-gated channel alpha subunit 5*ENSMUSG0000003251162
Scn3a / sodium channel, voltage-gated, type III, alpha / Q9NY46* / sodium voltage-gated channel alpha subunit 3*ENSMUSG0000005718257
Scn1a / A2APX8 / Sodium channel protein type 1 subunit alpha / P35498* / sodium voltage-gated channel alpha subunit 1*ENSMUSG0000006432957
Scn2a / sodium channel, voltage-gated, type II, alpha / Q99250* / sodium voltage-gated channel alpha subunit 2*ENSMUSG0000007531857
Scn8a / sodium channel, voltage-gated, type VIII, alpha / Q9UQD0* / sodium voltage-gated channel alpha subunit 8*ENSMUSG0000002303356
Scn9a / Q62205 / Sodium channel protein type 9 subunit alpha / Q15858* / sodium voltage-gated channel alpha subunit 9*ENSMUSG0000007531656
Scn4a / sodium channel, voltage-gated, type IV, alpha / P35499* / sodium voltage-gated channel alpha subunit 4*ENSMUSG0000000102753
Q9R053 / Scn11a / Sodium channel protein type 11 subunit alpha / Q9UI33* / sodium voltage-gated channel alpha subunit 11*ENSMUSG0000003411547
Scn7a / sodium voltage-gated channel alpha subunit 7 / Q01118*ENSMUSG0000003481035
Cacna1h / voltage-dependent T-type calcium channel subunit alpha-1H isoform 2 / O95180* / calcium voltage-gated channel subunit alpha1 H*ENSMUSG0000002411223
Cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSMUSG0000002086622
Cacna1i / calcium channel, voltage-dependent, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I*ENSMUSG0000002241622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR028809  Voltage gated sodium channel, alpha-10 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0019228 neuronal action potential IBA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization IEA
 biological_processGO:0061337 cardiac conduction IMP
 biological_processGO:0086010 membrane depolarization during action potential IBA
 biological_processGO:0086016 AV node cell action potential IEA
 biological_processGO:0086043 bundle of His cell action potential IEA
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0044299 C-fiber IDA
 cellular_componentGO:0071439 clathrin complex IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: C57BL/6J-Scn10aPsm

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
Show

Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: C57BL/6J-Scn10aPsm

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: C57BL/6J-Scn10aPsm

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: C57BL/6J-Scn10aPsm

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fat3tm1.2Good/Fat3+,Fjx1tm1Awp/Fjx1tm1Awp
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

Allelic Composition: S100a10tm1Jnw/S100a10tm1Jnw,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Scn10atm1Lex/Scn10atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

Allelic Composition: Hcn2tm1.1Lex/Hcn2tm1.1Lex,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn10atm1Lex/Scn10atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

Allelic Composition: Hcn2tm1.1Lex/Hcn2tm1.1Lex,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Oprd1tm1.1Cgrf/Oprd1tm1.1Cgrf,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: C57BL/6J-Scn10aPsm

Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: involves: C3H/HeN * C57BL/6J

Allelic Composition: Scn10aPsm/Scn10a+
Genetic Background: (C3H/HeN x C57BL/6J)F1

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: S100a10tm1Jnw/S100a10tm1Jnw,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003469 decreased single cell response intensity 
Show

Allelic Composition: S100a10tm1Jnw/S100a10tm1Jnw,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn10atm1Lex/Scn10atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scn10atm1Lex/Scn10atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcn2tm1.1Lex/Hcn2tm1.1Lex,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprd1tm1.1Cgrf/Oprd1tm1.1Cgrf,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprm1tm1.1Cgrf/Oprm1tm1.1Cgrf,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010504 abnormal RR interval "anomaly in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010637 sinus bradycardia "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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