ENSMUSG00000034652


Mus musculus

Features
Gene ID: ENSMUSG00000034652
  
Biological name :Cd300a
  
Synonyms : Cd300a / Mus musculus CD300A molecule (Cd300a), transcript variant 2, mRNA. / Q6SJQ0
  
Possible biological names infered from orthology : CD300a molecule / CD300C / CD300c molecule / Q08708 / Q9UGN4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 114890041
Gene end: 114904654
  
Corresponding Affymetrix probe sets: 10382438 (MoGene1.0st)   1435903_at (Mouse Genome 430 2.0 Array)   1445292_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036773
Ensembl peptide - ENSMUSP00000102192
NCBI entrez gene - 217303     See in Manteia.
MGI - MGI:2443411
RefSeq - XM_011248947
RefSeq - NM_001347654
RefSeq - NM_170758
RefSeq - XM_006533068
RefSeq - XM_006533069
RefSeq - XM_006533070
RefSeq Peptide - NP_739564
RefSeq Peptide - NP_001334583
swissprot - Q6SJQ0
Ensembl - ENSMUSG00000034652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD300LGENSGALG00000007713Gallus gallus
 CD300L-S1ENSGALG00000019755Gallus gallus
 CD300AENSG00000167851Homo sapiens
 CD300CENSG00000167850Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TSN2 / Cd300c2 / CD300C molecule 2 / Q9UGN4* / CD300C* / Q08708* / CD300A* / CD300c molecule* / CD300a molecule*ENSMUSG0000004481142
Cd300c / CMRF35-like molecule 6 / Q9UGN4* / Q08708* / CD300A* / CD300c molecule* / CD300a molecule*ENSMUSG0000005872832
Q6SJQ7 / Cd300lf / Mus musculus CD300 molecule like family member F (Cd300lf), transcript variant 3, mRNA.ENSMUSG0000004779824
Q1ERP8 / Cd300lg / CMRF35-like molecule 9 / Q6UXG3* / CD300 molecule like family member g*ENSMUSG0000001730923
Cd300ld2 / CD300 molecule like family member D2ENSMUSG0000008975322
Cd300e / Q8K249 / CMRF35-like molecule 2 / Q496F6* / CD300e molecule*ENSMUSG0000004849821
Q6SJQ5 / Cd300ld3 / CMRF35-like molecule 3 ENSMUSG0000006960721
Cd300ld4 / CD300 molecule like family member D4ENSMUSG0000006960921
Cd300ld5 / CD300 molecule like family member D5ENSMUSG0000008972221
Q8VCH2 / Cd300ld / CMRF35-like molecule 5 ENSMUSG0000003464119
Cd300lb / Mus musculus CD300 molecule like family member B (Cd300lb), transcript variant 2, mRNA. / A8K4G0* / CD300 molecule like family member b*ENSMUSG0000006319317


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002552 serotonin secretion by mast cell IDA
 biological_processGO:0006898 receptor-mediated endocytosis IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0014063 negative regulation of serotonin secretion IDA
 biological_processGO:0030889 negative regulation of B cell proliferation ISO
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0033007 negative regulation of mast cell activation involved in immune response ISO
 biological_processGO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway ISO
 biological_processGO:0043305 negative regulation of mast cell degranulation ISO
 biological_processGO:0043407 negative regulation of MAP kinase activity ISO
 biological_processGO:0048147 negative regulation of fibroblast proliferation ISO
 biological_processGO:0050856 regulation of T cell receptor signaling pathway ISO
 biological_processGO:0050859 negative regulation of B cell receptor signaling pathway ISO
 biological_processGO:0051134 negative regulation of NK T cell activation ISO
 biological_processGO:0060101 negative regulation of phagocytosis, engulfment ISO
 biological_processGO:1902564 negative regulation of neutrophil activation ISO
 biological_processGO:1902567 negative regulation of eosinophil activation ISO
 biological_processGO:1902569 negative regulation of activation of Janus kinase activity ISO
 biological_processGO:2000417 negative regulation of eosinophil migration ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 molecular_functionGO:0001786 phosphatidylserine binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008429 phosphatidylethanolamine binding ISO
 molecular_functionGO:0038023 signaling receptor activity ISO


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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