ENSMUSG00000034673


Mus musculus

Features
Gene ID: ENSMUSG00000034673
  
Biological name :Pbx2
  
Synonyms : O35984 / Pbx2 / pre B cell leukemia homeobox 2
  
Possible biological names infered from orthology : P40425 / PBX homeobox 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34591266
Gene end: 34597400
  
Corresponding Affymetrix probe sets: 10444394 (MoGene1.0st)   1418893_at (Mouse Genome 430 2.0 Array)   1418894_s_at (Mouse Genome 430 2.0 Array)   1449261_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040464
Ensembl peptide - ENSMUSP00000133744
Ensembl peptide - ENSMUSP00000133766
Ensembl peptide - ENSMUSP00000139079
NCBI entrez gene - 18515     See in Manteia.
MGI - MGI:1341793
RefSeq - NM_017463
RefSeq Peptide - NP_059491
swissprot - Q3UR63
swissprot - Q4FJL3
swissprot - V9GXB8
swissprot - O35984
swissprot - G3UXL9
Ensembl - ENSMUSG00000034673
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pbx2ENSDARG00000019717Danio rerio
 PBX2ENSG00000204304Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pbx3 / O35317 / Pre-B-cell leukemia transcription factor 3 / P40426* / PBX homeobox 3*ENSMUSG0000003871875
Pbx1 / P41778 / Pre-B-cell leukemia transcription factor 1 / P40424* / PBX homeobox 1*ENSMUSG0000005253474
Pbx4 / Q99NE9 / Mus musculus pre B cell leukemia homeobox 4 (Pbx4), transcript variant 4, mRNA. / Q9BYU1* / PBX homeobox 4*ENSMUSG0000003186055


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR005542  PBX
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009954 proximal/distal pattern formation IGI
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000090 absent premaxilla "missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,Tg(Tcfap2a-cre)1Will/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Pbx2tm1Mlc/Pbx2+,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mybtm1Cgn/Mybtm1Cgn,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004538 abnormal maxillary shelf "any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2tm1Mlc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,Tg(Tcfap2a-cre)1Will/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2tm1Mlc,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

 MP:0009902 abnormal lateral nasal prominence morphology "any structural anomaly of the lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009903 abnormal medial nasal prominence morphology "any structural anomaly of the central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009904 tongue hypoplasia "underdevelopment of the tongue, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0010940 abnormal maxillary prominence morphology 
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pbx1tm1Koss/Pbx1tm1Koss,Pbx2tm1Mlc/Pbx2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Pbx1tm1Mlc/Pbx1+,Pbx2tm1Mlc/Pbx2+,Pbx3tm1Mlc/Pbx3+
Genetic Background: involves: 129S6/SvEvTac

 MP:0030190 small snout "decreased size of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm1Mlc,Pbx2tm1Mlc/Pbx2+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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