ENSMUSG00000035064


Mus musculus

Features
Gene ID: ENSMUSG00000035064
  
Biological name :Eef2k
  
Synonyms : Eef2k / Eukaryotic elongation factor 2 kinase / O08796
  
Possible biological names infered from orthology : O00418
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 120842831
Gene end: 120907450
  
Corresponding Affymetrix probe sets: 10557009 (MoGene1.0st)   10557033 (MoGene1.0st)   1437829_s_at (Mouse Genome 430 2.0 Array)   1439860_at (Mouse Genome 430 2.0 Array)   1449013_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114782
Ensembl peptide - ENSMUSP00000115486
Ensembl peptide - ENSMUSP00000119567
Ensembl peptide - ENSMUSP00000046595
Ensembl peptide - ENSMUSP00000102096
Ensembl peptide - ENSMUSP00000102097
Ensembl peptide - ENSMUSP00000102098
NCBI entrez gene - 13631     See in Manteia.
MGI - MGI:1195261
RefSeq - XM_006507343
RefSeq - XM_006507345
RefSeq - XM_006507342
RefSeq - XM_006507344
RefSeq - NM_001267710
RefSeq - NM_001267711
RefSeq - NM_007908
RefSeq - XM_006507346
RefSeq Peptide - NP_001254640
RefSeq Peptide - NP_001254639
RefSeq Peptide - NP_031934
swissprot - O08796
swissprot - D3Z1Y3
swissprot - D3Z088
swissprot - F7A9F2
swissprot - F6ZEU2
Ensembl - ENSMUSG00000035064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eef2kENSDARG00000035835Danio rerio
 EEF2KENSGALG00000006982Gallus gallus
 EEF2KENSG00000103319Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alpk1 / alpha kinase 1 / Q96QP1*ENSMUSG0000002802815


Protein motifs (from Interpro)
Interpro ID Name
 IPR004166  MHCK/EF2 kinase
 IPR006597  Sel1-like repeat
 IPR011009  Protein kinase-like domain superfamily
 IPR017400  Eukaryotic elongation factor 2 kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006414 translational elongation TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031952 regulation of protein autophosphorylation IDA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071454 cellular response to anoxia IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 biological_processGO:1990637 response to prolactin IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004686 elongation factor-2 kinase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpgrtm1.1Sgj/Y
Genetic Background: involves: 129 * BALB/c

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrtm1.1Sgj/Y
Genetic Background: involves: 129 * BALB/c

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Rpgrtm1.1Sgj/Y
Genetic Background: involves: 129 * BALB/c

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpgrtm1.1Sgj/Y
Genetic Background: involves: 129 * BALB/c

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpgrtm1.1Sgj/Y
Genetic Background: involves: 129 * BALB/c

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Hp1bp3tm1a(EUCOMM)Wtsi/Hp1bp3+
Genetic Background: involves: C57BL/6N

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpgrtm1.1Sgj/Y
Genetic Background: involves: 129 * BALB/c

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpgrtm1.1Sgj/Y
Genetic Background: involves: 129 * BALB/c

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Eef2ktm1Agry/Eef2ktm1Agry
Genetic Background: B6.Cg-Eef2ktm1Agry

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hp1bp3tm1a(EUCOMM)Wtsi/Hp1bp3+
Genetic Background: involves: C57BL/6N

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eef2ktm1Agry/Eef2ktm1Agry
Genetic Background: B6.Cg-Eef2ktm1Agry

 MP:0009017 prolonged estrus "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eef2ktm1Agry/Eef2ktm1Agry
Genetic Background: B6.Cg-Eef2ktm1Agry

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Eef2ktm1Agry/Eef2ktm1Agry
Genetic Background: B6.Cg-Eef2ktm1Agry

 MP:0011120 increased primordial ovarian follicle number "greater than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
Show

Allelic Composition: Eef2ktm1Agry/Eef2ktm1Agry
Genetic Background: B6.Cg-Eef2ktm1Agry

 MP:0011124 increased primary ovarian follicle number "greater than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]
Show

Allelic Composition: Eef2ktm1Agry/Eef2ktm1Agry
Genetic Background: B6.Cg-Eef2ktm1Agry

 MP:0011128 increased secondary ovarian follicle number "greater than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]
Show

Allelic Composition: Eef2ktm1Agry/Eef2ktm1Agry
Genetic Background: B6.Cg-Eef2ktm1Agry

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020516 Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*  / reaction






 

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