ENSMUSG00000035637


Mus musculus

Features
Gene ID: ENSMUSG00000035637
  
Biological name :Grhpr
  
Synonyms : Glyoxylate reductase/hydroxypyruvate reductase / Grhpr / Q91Z53
  
Possible biological names infered from orthology : glyoxylate and hydroxypyruvate reductase / Q9UBQ7
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 44981395
Gene end: 44990734
  
Corresponding Affymetrix probe sets: 10504504 (MoGene1.0st)   1417772_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047218
Ensembl peptide - ENSMUSP00000120254
Ensembl peptide - ENSMUSP00000120061
Ensembl peptide - ENSMUSP00000117800
NCBI entrez gene - 76238     See in Manteia.
MGI - MGI:1923488
RefSeq - NM_080289
RefSeq - NM_001312880
RefSeq Peptide - NP_001299809
RefSeq Peptide - NP_525028
swissprot - Q91Z53
swissprot - B1AXQ0
swissprot - B0R075
swissprot - Q3T9Z2
swissprot - D6REG4
Ensembl - ENSMUSG00000035637
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grhpraENSDARG00000068264Danio rerio
 GRHPRENSGALG00000005423Gallus gallus
 GRHPRENSG00000137106Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006139  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
 IPR006140  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
 IPR029753  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007588 excretion IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0043648 dicarboxylic acid metabolic process IEA
 biological_processGO:0046487 glyoxylate metabolic process IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0008465 glycerate dehydrogenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016618 hydroxypyruvate reductase activity ISO
 molecular_functionGO:0030267 glyoxylate reductase (NADP) activity ISO
 molecular_functionGO:0031406 carboxylic acid binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002708 kidney stones "calculi occurring in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005360 urolithiasis "presence of calculi in any part of the urinary system" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85461, J:85462]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011517 hyperoxaluria "abnormally high levels of oxalic acid or oxalates in the urine; many metal ions form insoluble precipitates with oxalate, a prominent example being calcium oxalate, the primary constituent of the most common kind of kidney stones" [MGI:anna]
Show

Allelic Composition: Agxttm1Ull/Agxttm1Ull
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr