ENSMUSG00000035711


Mus musculus

Features
Gene ID: ENSMUSG00000035711
  
Biological name :Dok3
  
Synonyms : Docking protein 3 / Dok3 / Q9QZK7
  
Possible biological names infered from orthology : Q7L591
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 55523231
Gene end: 55529296
  
Corresponding Affymetrix probe sets: 10409502 (MoGene1.0st)   1418096_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046695
Ensembl peptide - ENSMUSP00000153308
NCBI entrez gene - 27261     See in Manteia.
MGI - MGI:1351490
RefSeq - XM_017315524
RefSeq - NM_013739
RefSeq Peptide - NP_038767
swissprot - Q14AA1
swissprot - Q9QZK7
Ensembl - ENSMUSG00000035711
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DOK3ENSGALG00000026914Gallus gallus
 DOK3ENSG00000146094Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dok2 / O70469 / Docking protein 2 / O60496*ENSMUSG0000002210230
Dok1 / P97465 / Docking protein 1 / Q99704*ENSMUSG0000006833530
Dok6 / Q2MHE5 / Docking protein 6 / Q6PKX4*ENSMUSG0000007351416
Dok5 / Q91ZM9 / Docking protein 5 / Q9P104*ENSMUSG0000002756015
Dok4 / Q99KE3 / Docking protein 4 / Q8TEW6*ENSMUSG0000004063115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007265 Ras protein signal transduction IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Pax7tm1(cre/Esr1*)Cklr/Pax7tm1(cre/Esr1*)Cklr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok3tm1Ppp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004202 pulmonary hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: F2rtm1Pago/F2rtm1Pago,F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: B6.129-F3tm1.1Dwr F2rtm1Pago

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0010829 increased bronchioalveolar stem cell number 
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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