ENSMUSG00000036006


Mus musculus

Features
Gene ID: ENSMUSG00000036006
  
Biological name :Ripor2
  
Synonyms : Q80U16 / RHO family interacting cell polarization regulator 2 / Ripor2
  
Possible biological names infered from orthology : Q9Y4F9
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 24582189
Gene end: 24733816
  
Corresponding Affymetrix probe sets: 10404152 (MoGene1.0st)   1434359_at (Mouse Genome 430 2.0 Array)   1453837_at (Mouse Genome 430 2.0 Array)   1458202_at (Mouse Genome 430 2.0 Array)   1460555_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115689
Ensembl peptide - ENSMUSP00000106012
Ensembl peptide - ENSMUSP00000106013
Ensembl peptide - ENSMUSP00000043663
Ensembl peptide - ENSMUSP00000051342
Ensembl peptide - ENSMUSP00000089286
NCBI entrez gene - 193385     See in Manteia.
MGI - MGI:2444879
RefSeq - XM_006516595
RefSeq - NM_178658
RefSeq - XM_006516587
RefSeq - XM_006516588
RefSeq - XM_006516589
RefSeq - XM_006516590
RefSeq - XM_006516591
RefSeq - XM_006516592
RefSeq - XM_006516594
RefSeq - NM_001080381
RefSeq - NM_001286100
RefSeq - NM_001286101
RefSeq - NM_029679
RefSeq Peptide - NP_083955
RefSeq Peptide - NP_001073850
RefSeq Peptide - NP_001273029
RefSeq Peptide - NP_848773
RefSeq Peptide - NP_001273030
swissprot - Q80U16
swissprot - F2Z3V4
swissprot - A6PW28
Ensembl - ENSMUSG00000036006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q1LU99ENSDARG00000061752Danio rerio
 ENSGALG00000041452Gallus gallus
 FAM65BENSGALG00000013624Gallus gallus
 Q9Y4F9ENSG00000111913Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q68FE6 / Ripor1 / Rho family-interacting cell polarization regulator 1 / Q6ZS17*ENSMUSG0000003860437
A1L3T7 / Ripor3 / RIPOR family member 3 / Q96MK2*ENSMUSG0000007457731


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026136  RIPOR family member 3
 IPR031780  FAM65, N-terminal
 IPR033035  Rho family-interacting cell polarization regulator 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007162 negative regulation of cell adhesion ISS
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007605 sensory perception of sound ISS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction ISS
 biological_processGO:0042130 negative regulation of T cell proliferation ISO
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045663 positive regulation of myoblast differentiation ISO
 biological_processGO:0048741 skeletal muscle fiber development IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051491 positive regulation of filopodium assembly ISO
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:0071158 positive regulation of cell cycle arrest ISO
 biological_processGO:0071260 cellular response to mechanical stimulus IMP
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IMP
 biological_processGO:1901673 regulation of mitotic spindle assembly ISO
 biological_processGO:1901741 positive regulation of myoblast fusion ISS
 biological_processGO:1903904 negative regulation of establishment of T cell polarity ISO
 biological_processGO:1905872 negative regulation of protein localization to cell leading edge IMP
 biological_processGO:1990869 cellular response to chemokine ISS
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 biological_processGO:2000391 positive regulation of neutrophil extravasation IMP
 biological_processGO:2000405 negative regulation of T cell migration ISO
 biological_processGO:2001107 negative regulation of Rho guanyl-nucleotide exchange factor activity IMP
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0032420 stereocilium ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060171 stereocilium membrane ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IMP
 molecular_functionGO:0071889 14-3-3 protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0004525 thin cochlear hair cell stereocilia "reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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