ENSMUSG00000036098


Mus musculus

Features
Gene ID: ENSMUSG00000036098
  
Biological name :Myrf
  
Synonyms : Myelin regulatory factor Myelin regulatory factor, N-terminal Myelin regulatory factor, C-terminal / Myrf / Q3UR85
  
Possible biological names infered from orthology : myelin regulatory factor / Q9Y2G1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 10208272
Gene end: 10240748
  
Corresponding Affymetrix probe sets: 10465916 (MoGene1.0st)   1439506_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085329
Ensembl peptide - ENSMUSP00000139601
Ensembl peptide - ENSMUSP00000140838
Ensembl peptide - ENSMUSP00000140871
NCBI entrez gene - 225908     See in Manteia.
MGI - MGI:2684944
RefSeq - XM_011247222
RefSeq - NM_001033481
RefSeq - XM_006526932
RefSeq - XM_006526933
RefSeq - XM_006526934
RefSeq - XM_006526927
RefSeq - XM_006526928
RefSeq - XM_006526929
RefSeq - XM_006526930
RefSeq - XM_006526931
RefSeq Peptide - NP_001028653
swissprot - Q3UR85
swissprot - A0A087WRZ9
Ensembl - ENSMUSG00000036098
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myrfENSDARG00000078676Danio rerio
 MYRFENSGALG00000041253Gallus gallus
 MYRFENSG00000124920Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myrfl / Q3UN70 / Myelin regulatory factor-like protein / Q96LU7* / myelin regulatory factor-like*ENSMUSG0000003405733


Protein motifs (from Interpro)
Interpro ID Name
 IPR008967  p53-like transcription factor, DNA-binding
 IPR024061  NDT80 DNA-binding domain
 IPR025719  Myelin gene regulatory factor C-terminal domain 2
 IPR026932  Myelin gene regulatory factor C-terminal domain 1
 IPR026933  Myelin gene regulatory factor
 IPR030392  Intramolecular chaperone auto-processing domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR037141  NDT80 DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0022010 central nervous system myelination IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031643 positive regulation of myelination IMP
 biological_processGO:0032286 central nervous system myelin maintenance IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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